Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis


Por: Bos, K, Harkins, K, Herbig, A, Coscolla, M, Weber, N, Comas, I, Forrest, S, Bryant, J, Harris, S, Schuenemann, V, Campbell, T, Majander, K, Wilbur, A, Guichon, R, Steadman, D, Cook, D, Niemann, S, Behr, M, Zumarraga, M, Bastida, R, Huson, D, Nieselt, K, Young, D, Parkhill, J, Buikstra, J, Gagneux, S, Stone, A and Krause, J

Fecha de Publicación: 23/10/2014
Categoría: Multidisciplinary

Resumen:
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact(1). This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World(2). Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch(3), although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

Direcciones
Bos, KI: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany
Harkins, KM: Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA
Herbig, A: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany; Univ Tubingen, Ctr Bioinformat, D-72076 Tubingen, Germany
Coscolla, M: Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland; Univ Basel, CH-4003 Basel, Switzerland
Weber, N: Univ Tubingen, Ctr Bioinformat, D-72076 Tubingen, Germany
Comas, I: FISABIO Publ Hlth, Genom & Hlth Unit, Valencia 46020, Spain; Inst Salud Carlos III, CIBER Ctr Invest Biomed Red Epidemiol & Publ Hlth, Madrid 28029, Spain
Forrest, SA: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany
Bryant, JM: Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
Schuenemann, VJ: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany
Campbell, TJ: Univ Cape Town, Dept Archaeol, ZA-7701 Rondebosch, South Africa
Majander, K: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany
Wilbur, AK: Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA
Guichon, RA: UNMDP, FCEyN, Dept Biol, CONICET,Lab Ecologia Evolut Humana FACSO,UNCPBA, RA-7631 Quequen, Argentina
Steadman, DLW: Univ Tennessee, Dept Anthropol, Knoxville, TN 37996 USA
Cook, DC: Indiana Univ, Dept Anthropol, Bloomington, IN 47405 USA
Niemann, S: Forschungszentrum Borstel, D-23845 Borstel, Germany; Forschungszentrum Borstel, German Ctr Infect Res, D-23845 Borstel, Germany
Behr, MA: McGill Univ, McGill Int TB Ctr, Montreal, PQ H3G 1A4, Canada
Zumarraga, M: CICVyA INTA Castelar, Inst Biotechnol, Buenos Aires, DF, Argentina
Bastida, R: Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Inst Invest Marinas & Costeras CONICET UNMcP, RA-7600 Mar Del Plata, Buenos Aires, Argentina
Huson, D: Univ Tubingen, Ctr Bioinformat, D-72076 Tubingen, Germany
Nieselt, K: Univ Tubingen, Ctr Bioinformat, D-72076 Tubingen, Germany
Young, D: Univ London Imperial Coll Sci Technol & Med, Dept Med, London W2 1PG, England; MRC Natl Inst Med Res, Div Mycobacterial Res, London NW7 1AA, England
Parkhill, J: Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
Buikstra, JE: Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA
Gagneux, S: Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland; Univ Basel, CH-4003 Basel, Switzerland
Stone, AC: Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA
Krause, J: Univ Tubingen, Dept Archaeol Sci, D-72070 Tubingen, Germany; Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenvironm, D-72070 Tubingen, Germany; Max Planck Inst Sci & Hist, D-07745 Jena, Germany
ISSN: 00280836





Nature
Editorial
NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 514 Número: 7523
Páginas: 494-s
WOS: 000343775900041
ID de PubMed: 25141181

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