A novel common variant in DCST2 is associated with length in early life and height in adulthood

Por: van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Davey Smith G, Bergström A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M, Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CM, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen AL, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikäinen LP, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw SM, Holloway JW, Melén E, Grant SF, Feenstra B, Lowe WL, Widén E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin MR, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, Mccarthy MI, Frayling TM, Sunyer J, Timpson NJ, Rivadeneira F, Bønnelykke K, Jaddoe VW and Early Growth Genetics (EGG) Consortium

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Publicada: 15 feb 2015 Ahead of Print: 3 oct 2014

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Filiaciones:
van der Valk RJ:
 Department of Epidemiology, Department of Paediatrics, The Generation R Study Group

Kreiner-Møller E:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Kooijman MN:
 Department of Epidemiology, Department of Paediatrics, The Generation R Study Group

Guxens M:
 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain

Stergiakouli E:
 MRC Integrative Epidemiology Unit

Sääf A:
 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Bradfield JP:
 Center for Applied Genomics, Abramson Research Center

Geller F:
 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Hayes MG:
 Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Cousminer DL:
 Institute for Molecular Medicine Finland

Körner A:
 Center of Pediatric Research, University Hospital Center Leipzig, University of Leipzig, Leipzig, Germany

Thiering E:
 Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany, Institute of Epidemiology I

Curtin JA:
 Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK

Myhre R:
 Division Epidemiology, Department Genes and Environment

Huikari V:
 Institute of Health Sciences

Joro R:
 Institute of Biomedicine, Physiology

Kerkhof M:
 Department of Epidemiology, Groningen Research Institute for Asthma and COPD

Warrington NM:
 School of Women's and Infants' Health, The University of Western Australia, Perth, Australia, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

Pitkänen N:
 Research Centre of Applied and Preventive Cardiovascular Medicine

Ntalla I:
 Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK, Department of Nutrition and Dietetics, Harokopio University of Athens, Athens 11527, Greece

Horikoshi M:
 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK

Veijola R:
 Department of Pediatrics, Medical Research Center

Freathy RM:
 University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK

Teo YY:
 Saw Swee Hock School of Public Health, Life Science Institute, National University of Singapore, Singapore, Genome Institute of Singapore, Agency for Science, Technology and Research

Barton SJ:
 MRC Lifecourse Epidemiology Unit

Evans DM:
 MRC Integrative Epidemiology Unit , University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

Kemp JP:
 MRC Integrative Epidemiology Unit , University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

St Pourcain B:
 MRC Integrative Epidemiology Unit , Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, School of Oral and Dental Sciences, University of Bristol, Bristol, UK

Ring SM:
 MRC Integrative Epidemiology Unit , Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine

Davey Smith G:
 MRC Integrative Epidemiology Unit

Bergström A:
 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Kull I:
 Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden, Sachs' Children's Hospital, Stockholm, Sweden

Hakonarson H:
 Center for Applied Genomics, Abramson Research Center, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Mentch FD:
 Center for Applied Genomics, Abramson Research Center

Bisgaard H:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Chawes B:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Stokholm J:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Waage J:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Eriksen P:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Sevelsted A:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Melbye M:
 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Department of Medicine, Stanford School of Medicine, Stanford, USA

van Duijn CM:
 Department of Epidemiology

Medina-Gomez C:
 Department of Epidemiology, The Generation R Study Group, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Hofman A:
 Department of Epidemiology, The Generation R Study Group

de Jongste JC:
 Department of Paediatrics, The Generation R Study Group

Taal HR:
 Department of Epidemiology, Department of Paediatrics

Uitterlinden AG:
 Department of Epidemiology, The Generation R Study Group, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Armstrong LL:
 Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Eriksson J:
 Institute for Molecular Medicine Finland

Palotie A:
 Institute for Molecular Medicine Finland, Analytic and Translational Genetics Unit, Department of Medicine, Program in Medical and Population Genetics, Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA

Bustamante M:
 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain, Centre for Genomic Regulation (CRG), Barcelona, Spain

Estivill X:
 CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain, Centre for Genomic Regulation (CRG), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

Gonzalez JR:
 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain

:
 CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Valencia, Spain

Kiess W:
 Center of Pediatric Research, University Hospital Center Leipzig, University of Leipzig, Leipzig, Germany

Mahajan A:
 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK

Flexeder C:
 Institute of Epidemiology I

Tiesler CM:
 Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany, Institute of Epidemiology I

Murray CS:
 Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK

Simpson A:
 Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK

Magnus P:
 Division Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

Sengpiel V:
 Department Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden

Hartikainen AL:
 Institute of Clinical Medicine/Obstetrics and Gynecology

Keinanen-Kiukaanniemi S:
 Institute of Health Sciences

Lewin A:
 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health

Da Silva Couto Alves A:
 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health

Blakemore AI:
 Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine, Imperial College, London W12 0NN, UK

Buxton JL:
 Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine, Imperial College, London W12 0NN, UK

Kaakinen M:
 Institute of Health Sciences, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health, Biocenter Oulu, University of Oulu, Oulu, Finland

Rodriguez A:
 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health, Department of Psychology, Mid Sweden University, Östersund, Sweden

Sebert S:
 Institute of Health Sciences

Vaarasmaki M:
 Department of Obstetrics and Gynecology and MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland

Lakka T:
 Institute of Biomedicine, Physiology, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland

Lindi V:
 Institute of Biomedicine, Physiology

Gehring U:
 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands

Postma DS:
 Groningen Research Institute for Asthma and COPD, Department of Pulmonology

Ang W:
 School of Women's and Infants' Health, The University of Western Australia, Perth, Australia

Newnham JP:
 School of Women's and Infants' Health, The University of Western Australia, Perth, Australia

Lyytikäinen LP:
 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland

Pahkala K:
 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

Raitakari OT:
 Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine

Panoutsopoulou K:
 Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1HH, UK

Zeggini E:
 Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1HH, UK

Boomsma DI:
 Department of Biological Psychology, VU University, Amsterdam, The Netherlands, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, The Netherlands

Groen-Blokhuis M:
 Department of Biological Psychology, VU University, Amsterdam, The Netherlands, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, The Netherlands

Ilonen J:
 Immunogenetics Laboratory, University of Turku, Turku, Finland, Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland

Franke L:
 Department of Genetics, University of Groningen, University Medical Centre Groningen, The Netherlands

Hirschhorn JN:
 Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Department of Genetics, Harvard Medical School, USA

Pers TH:
 Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Denmark

Liang L:
 Department of Pediatrics, Tampere University Hospital, Tampere, Finland

Huang J:
 Department of Pediatrics, Tampere University Hospital, Tampere, Finland, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China

Hocher B:
 Institute of Nutritional Science, University of Potsdam, Germany, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China, Center for Cardiovascular Research/Institute of Pharmacology, Charité, Berlin, Germany

Knip M:
 Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland, Department of Pediatrics, Tampere University Hospital, Tampere, Finland, Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

Saw SM:
 Saw Swee Hock School of Public Health, Singapore Eye Research Institute, Singapore, Duke-NUS Graduate Medical School, Singapore

Holloway JW:
 Human Genetics and Genomic Medicine, Human Development & Health, Faculty of Medicine, University of Southampton, UK

Melén E:
 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Sachs' Children's Hospital, Stockholm, Sweden

Grant SF:
 Center for Applied Genomics, Abramson Research Center, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Feenstra B:
 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Lowe WL:
 Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Widén E:
 Institute for Molecular Medicine Finland

Sergeyev E:
 Center of Pediatric Research, University Hospital Center Leipzig, University of Leipzig, Leipzig, Germany

Grallert H:
 Institute of Epidemiology II, Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

Custovic A:
 Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK

Jacobsson B:
 Division Epidemiology, Department Genes and Environment, Department Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden

Atalay M:
 Institute of Biomedicine, Physiology

Koppelman GH:
 Groningen Research Institute for Asthma and COPD, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Pennell CE:
 School of Women's and Infants' Health, The University of Western Australia, Perth, Australia

Niinikoski H:
 Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Pediatrics, Turku University Hospital, Turku, Finland

Dedoussis GV:
 Department of Nutrition and Dietetics, Harokopio University of Athens, Athens 11527, Greece

Mccarthy MI:
 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK

Frayling TM:
 University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK

Sunyer J:
 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

Timpson NJ:
 MRC Integrative Epidemiology Unit

Rivadeneira F:
 Department of Epidemiology, The Generation R Study Group, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Bønnelykke K:
 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

Jaddoe VW:
 Department of Epidemiology, Department of Paediatrics, The Generation R Study Group,

Institute of Health Sciences, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPE) Centre for Environment and Health, Biocenter Oulu, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220, Oulu 90029 OYS, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, Oulu FI-90101, Finland a