Zinc and smoking habits in the setting of hypertension in a Spanish populations.


Por: Suarez-Varela MM, Llopis-González A, González Albert V, López-Izquierdo R, González-Manzano I, Cháves J, Biosca VH and Martin-Escudero JC

Fecha de Publicación: 01/02/2015
Resumen:
The objective of this study was to evaluate the relationship between trace and toxic amounts of zinc (Zn) in biological samples (blood and urine) and the smoking habits of hypertensive patients and healthy control subjects in Valladolid (Spain). In order to compare biological samples, the concentrations of these samples were measured using inductively coupled plasma mass spectrometry. The limits of detection for Zn in blood plasma ranged between 4.22 and 17.34 µmol l(-1) and were <0.08 µmol g(-1) creatinine in urine. The results of this study indicate that the highest mean values of serum Zn were found in non-hypertensive nonsmokers (13.39±4.35 µmol l(-1)), whereas the highest urine Zn values were observed in hypertensive nonsmokers (2.78±2.13 µmol l(-1)). Higher Zn serum/urine quotient levels were observed in non-hypertensive and nonsmoking women, whereas lower levels were noted in non-hypertensive and smoking women (P=0.012). This study identified a correlation between Zn serum/urine quotients and cotinine levels (a marker of smoking), a correlation that suggests that smoking lowers the Zn serum/urine quotient, which was lower in hypertensive subjects than in control subjects.

Direcciones
Suarez-Varela MM: 1] Unidad de Salud Pública y Sanidad Ambiental, Departamento de Medicina Preventiva, Universidad de Valencia, Valencia, Spain [2] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain [3] Centro Superior de Investigaciones en Salud Pública (CSISP-FISABIO), Valencia, Spain
Llopis-González A: 1] Unidad de Salud Pública y Sanidad Ambiental, Departamento de Medicina Preventiva, Universidad de Valencia, Valencia, Spain [2] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain [3] Centro Superior de Investigaciones en Salud Pública (CSISP-FISABIO), Valencia, Spain
González Albert V: Unidad de Genotipado y Diagnóstico Genético, Fundación Investigación Clínico de Valencia-INCLIVA, Valencia, Spain
López-Izquierdo R: Departamento de Medicina Interna, Hospital Rio Hortega, Universidad de Valladolid, Valladolid, Spain
González-Manzano I: Departamento de Medicina Interna, Hospital Rio Hortega, Universidad de Valladolid, Valladolid, Spain
Cháves J: 1] Unidad de Genotipado y Diagnóstico Genético, Fundación Investigación Clínico de Valencia-INCLIVA, Valencia, Spain [2] CIBER de Diabetes y Enfermedades Metabólicas Asociados (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Biosca VH: Unidad de Salud Pública y Sanidad Ambiental, Departamento de Medicina Preventiva, Universidad de Valencia, Valencia, Spain
Martin-Escudero JC: Departamento de Medicina Interna, Hospital Rio Hortega, Universidad de Valladolid, Valladolid, Spain
ISSN: 09169636





HYPERTENS RES
Editorial
Nature Publishing Group, Reino Unido
Tipo de documento: Article
Volumen: 38 Número: 2
Páginas: 149-154s
WOS: 000349464200010
ID de PubMed: 25273553

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