Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz.


Por: Blas-García A, Polo M, Alegre F, Funes HA, Martínez E, Apostolova N and Esplugues JV

Publicada: 1 nov 2014
Resumen:
Growing evidence associates the non-nucleoside reverse transcriptase inhibitor efavirenz with several adverse events. Newer antiretrovirals, such as the integrase inhibitor raltegravir, the non-nucleoside reverse transcriptase inhibitor rilpivirine and the protease inhibitor darunavir, claim to have a better toxicological profile than efavirenz while producing similar levels of efficacy and virological suppression. The objective of this study was to determine the in vitro toxicological profile of these three new antiretrovirals by evaluating their effects on the mitochondrial and cellular parameters altered by efavirenz in hepatocytes and neurons.
ISSN: 03057453





JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Editorial
OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 69 Número: 11
Páginas: 2995-3000
WOS Id: 000344605500019
ID de PubMed: 25011651
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