Role of Vitamin A in Mammary Gland Development and Lactation
Por:
Cabezuelo MT, Zaragozá R, Barber T and Viña JR
Publicada:
1 ene 2020
Resumen:
Vitamin A (all-trans-retinol), its active derivatives retinal and retinoic acid, and their synthetic analogues constitute the group of retinoids. It is obtained from diet either as preformed vitamin A or as carotenoids. Retinal plays a biological role in vision, but most of the effects of vitamin A are exerted by retinoic acid, which binds to nuclear receptors and regulates gene transcription. Vitamin A deficiency is an important nutritional problem, particularly in the developing world. Retinol and carotenoids from diet during pregnancy and lactation influence their concentration in breast milk, which is important in the long term, not only for the offspring, but also for maternal health. In this study, we review the role of vitamin A in mammary gland metabolism, where retinoid signaling is required not only for morphogenesis and development of the gland and for adequate milk production, but also during the weaning process, when epithelial cell death is coupled with tissue remodeling.
Filiaciones:
:
Department of Physiology, Universitat de València, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain
University Hospital Doctor Peset, Gaspar Aguilar, 90, 46017 Valencia, Spain
Zaragozá R:
Department of Human Anatomy and Embryology-INCLIVA Biomedical Research Institute, Universitat de València, 46010 Valencia, Spain
Barber T:
Department of Biochemistry and Molecular Biology-INCLIVA Biomedical Research Institute, Universitat de València, 46010 Valencia, Spain
Viña JR:
Department of Biochemistry and Molecular Biology-INCLIVA Biomedical Research Institute, Universitat de València, 46010 Valencia, Spain
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