Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain)
Por:
Lozano M, Murcia M, Soler-Blasco R, Iñiguez C, Irizar A, Lertxundi A, Basterrechea M, Marina LS, Amorós R, Broberg K, Ballester F and Llop S
Publicada:
1 feb 2020
Ahead of Print:
19 nov 2019
Resumen:
We assessed whether prenatal selenium (Se) exposure is associated with anthropometry at birth, placental weight and gestational age. Study subjects were 1249 mother-child pairs from the Valencia and Gipuzkoa cohorts of the Spanish Childhood and Environment Project (INMA, 2003-2008). Se was determined in serum samples taken at the first trimester of pregnancy. Socio-demographic and dietary characteristics were also collected by questionnaires. Mean (SD) serum Se concentration was 79.57 (9.64) mu g/L. Se showed weak associations with both head circumference and gestational age. The association between serum Se concentration and birth weight and length was negative, and direct for placental weight and probability of preterm birth, although the coefficients did not reach statistical significance. Individuals with total mercury (THg) levels > 15 mu g/L reversed the serum Se concentration effect on head circumference. Significant interactions were found between sex and both gestational age and prematurity. Spontaneous birth gestational ages were estimated to be lower for males and their probability of prematurity was higher. In conclusion, prenatal Se exposure may be associated with lower head circumference and lower gestational ages at spontaneous birth. Interactions with THg exposure and gender should be considered when assessing these relationships.
Filiaciones:
:
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, Spain
Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department. Universitat de València, València, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Department of Statistics and Computational Research. Universitat de València, València, Spain
Irizar A:
Health Research Institute, BIODONOSTIA, San Sebastian, Gipuzkoa, Spain
Lertxundi A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Preventive Medicine and Public Health Department. University of Basque Country, UPV/EHU, Leioa, Bizkaia, Spain
Health Research Institute, BIODONOSTIA, San Sebastian, Gipuzkoa, Spain
Basterrechea M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Preventive Medicine and Public Health Department. University of Basque Country, UPV/EHU, Leioa, Bizkaia, Spain
Health Research Institute, BIODONOSTIA, San Sebastian, Gipuzkoa, Spain
Marina LS:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Preventive Medicine and Public Health Department. University of Basque Country, UPV/EHU, Leioa, Bizkaia, Spain
Health Research Institute, BIODONOSTIA, San Sebastian, Gipuzkoa, Spain
:
School of Mathematics, Peter Guthrie Tait Road, University of Edinburgh, EH9 3FD, Edinburgh, United Kingdom
Broberg K:
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Nursing Department, Universitat de València, València, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Green Accepted
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