Deficit of interleukin 7 in septic patients
Por:
Andreu-Ballester JC, Cuellar C, Garcia-Ballesteros C, Pérez-Griera J, Amigó V, Peiró-Gómez A, Peñarroja-Otero C, Ballester F, Mayans J and Tormo-Calandín C
Publicada:
1 nov 2014
Resumen:
We recently demonstrated an overall decrease of all alpha beta and specially gamma delta T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of gamma delta T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients who met criteria for sepsis were analyzed vs control group. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. The frequency gamma delta T cells at admission was lower in septic patients vs control group. At the time of admission, the frequency of gamma delta T cells in septic patients who subsequently died was lower than the observed in the group of patients that instead survived. (C) 2014 Elsevier B.V. All rights reserved.
Filiaciones:
:
Research Department, Arnau de Vilanova Hospital, Valencia, Spain
Cuellar C:
Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain
:
Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain
Pérez-Griera J:
Biopathology Department, Clinic Universitary Hospital, Valencia, Spain
:
Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain
:
Emergency Department, Arnau de Vilanova Hospital, Valencia, Spain
Peñarroja-Otero C:
Casa de la Salud Hospital, Valencia, Spain
:
Faculty of Nursing, University of Valencia, Spain
:
Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain
Tormo-Calandín C:
Catholic University School of Medicine, Valencia, Spain
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