Comparison of Foveal, Macular, and Peripapillary Intraretinal Thicknesses Between Autism Spectrum Disorder and Neurotypical Subjects


Por: García-Medina JJ, García-Piñero M, Del-Río-Vellosillo M, Fares-Valdivia J, Ragel-Hernández AB, Martínez-Saura S, Cárcel-López MD, Zanon-Moreno V, Pinazo-Duran MD and Villegas-Pérez MP

Publicada: 1 nov 2017
Resumen:
PURPOSE. To compare thicknesses of intraretinal layers segmented by spectral-domain optical coherence tomography (SD-OC) between autism spectrum disorder (ASD) and neurotypical (NT) individuals. METHODS. We performed 2 scans on 108 eyes from 54 participants (27 high-functioning ASD and 27 age-and sex-matched NT subjects): macular fast volume and peripapillary retinal nerve fiber layer (pRNFL). Macula was automatically segmented. The mean foveal and macular thickness of nine different layers and the thickness of nine pRNFL sectors were considered. Data from the right and left eyes were averaged for each participant. The results were compared between the ASD and NT groups. Associations between the Kaufman brief intelligence test (K-BIT), head circumference and SD-OCT results were also investigated in ASD individuals. RESULTS. ASD subjects showed greater foveal thickness at total retina, total inner retina, inner plexiform and inner nuclear layers, and greater macular thickness at total retina and total inner retina. Inferior, nasal inferior and temporal inferior sectors of pRNFL were also thicker in the ASD participants than in the controls (P < 0.05, unpaired t-test). Significant correlations were found between some K-BIT results and temporal inferior and inferior pRNFL thicknesses in the ASD group (P < 0.05, Spearman's rank correlation). No associations were seen between head circumference and OCT parameters. CONCLUSIONS. There are intraretinal thickenings at different locations in ASD subjects when compared to NT controls. This fact should be taken into account when interpreting SD-OCT examinations in ASD individuals. Plus, some pRNFL thicknesses present positive correlations with scores of cognitive status in ASD.

Filiaciones:
:
 General University Hospital Reina Sofia, Murcia, Spain

 Department of Ophthalmology, Optometry, Otolaryngology and Pathology. School of Medicine, University of Murcia, Spain

 Ophthalmic Research Unit "Santiago Grisolia", Valencia, Spain

 Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, Madrid, Spain

García-Piñero M:
 Faculty of Biology, University of Murcia, Spain

Del-Río-Vellosillo M:
 University Hospital Virgen de la Arrixaca, Murcia, Spain

Fares-Valdivia J:
 General University Hospital Reina Sofia, Murcia, Spain

Ragel-Hernández AB:
 Integral Formation Center "Gabriel Perez Carcel", Murcia, Spain

Martínez-Saura S:
 Asociación para la atención de personas con trastornos generalizados del desarrollo de la región de Murcia (ASTRADE), Murcia, Spain

Cárcel-López MD:
 Integral Formation Center "Gabriel Perez Carcel", Murcia, Spain

:
 Ophthalmic Research Unit "Santiago Grisolia", Valencia, Spain

 Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, Madrid, Spain

 Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain

:
 Ophthalmic Research Unit "Santiago Grisolia", Valencia, Spain

 Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, Madrid, Spain

 Department of Ophthalmology, School of Medicine, University of Valencia, Spain

Villegas-Pérez MP:
 General University Hospital Reina Sofia, Murcia, Spain

 Department of Ophthalmology, Optometry, Otolaryngology and Pathology. School of Medicine, University of Murcia, Spain

 Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, Madrid, Spain
ISSN: 01460404





INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Editorial
ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 58 Número: 13
Páginas: 5811-5818
WOS Id: 000419071600023
ID de PubMed: 29131901
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