Gut microbiota disturbance during antibiotic therapy A multi-omic approach
Por:
Ferrer M, Martins dos Santos VA, Ott SJ and Moya A
Publicada:
1 ene 2014
Resumen:
It is known that the gastrointestinal tract (GIT) microbiota responds to different antibiotics in different ways and that while some antibiotics do not induce disturbances of the community, others drastically influence the richness, diversity, and prevalence of bacterial taxa. However, the metabolic consequences thereof, independent of the degree of the community shifts, are not clearly understood. In a recent article, we used an integrative OMICS approach to provide new insights into the metabolic shifts caused by antibiotic disturbance. The study presented here further suggests that specific bacterial lineage blooms occurring at defined stages of antibiotic intervention are mostly associated with organisms that possess improved survival and colonization mechanisms, such as those of the Enterococcus, Blautia, Faecalibacterium, and Akkermansia genera. The study also provides an overview of the most variable metabolic functions affected as a consequence of a beta-lactam antibiotic intervention. Thus, we observed that anabolic sugar metabolism, the production of acetyl donors and the synthesis and degradation of intestinal/colonic epithelium components were among the most variable functions during the intervention. We are aware that these results have been established with a single patient and will require further confirmation with a larger group of individuals and with other antibiotics. Future directions for exploration of the effects of antibiotic interventions are discussed.
Filiaciones:
Ferrer M:
Consejo Superior de Investigaciones Científicas (CSIC)
Institute of Catalysis
Madrid, Spain
Martins dos Santos VA:
Chair of Systems and Synthetic Biology
Wageningen University
Wageningen, the Netherlands
LifeGlimmer GmbH
Berlin, Germany
Ott SJ:
Institute for Clinical Molecular Biology at the Christian-Albrechts University
Kiel, Germany
Department for Internal Medicine
University Hospital Schleswig-Holstein, Campus Kiel
:
Unidad Mixta de Investigación en Genómica y Salud de la Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Salud Pública
Valencia, Spain
Instituto Cavanilles de Biodiversidad y Biología Evolutiva de la Universitat de València
CIBER en Epidemiología y Salud Pública (CIBEResp)
Madrid, Spain
Green Published, Bronze
|