Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression
Por:
Restrepo C, Gutierrez-Rivas M, Pacheco YM, García M, Blanco J, Medrano LM, Navarrete-Muñoz MA, Gutiérrez F, Miralles P, Dalmau D, Gómez JL, Górgolas M, Cabello A, Resino S, Benito JM and Rallón N
Publicada:
28 mar 2019
Categoría:
Multidisciplinary
Resumen:
Objective
We investigated the association of genetic polymorphisms in chemokine and chemokine receptor genes with poor immunological recovery in HIV patients starting combined antiretroviral therapy (cART) with low CD4 T-cell counts.
Methods
A case-control study was conducted in 412 HIV-infected patients starting cART with CD4 T-cell count <200 cells/mu L and successful viral control for two years. CD4 count increase below 200 cells/mu L after two years on cART was used to define INR (immunological nonresponder) patients. Polymorphisms in CXCL12, CCL5 and CCR2 genes were genotyped using sequenom's MassARRAY platform.
Results
Thirty two percent (134/412) of patients were classified as INR. After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL1 2 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06).
Conclusions
CCR2 rs1799864-AG or CXCL12 rs1801157-TT genotypes influence on the probability of poor CD4 recovery in the population of HIV patients starting cART with low CD4 counts. Genotyping of these polymorphisms could be used to estimate the risk of poor CD4 restoration, mainly in patients who are diagnosed late in the course of infection.
Filiaciones:
Restrepo C:
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
Gutierrez-Rivas M:
Instituto de Salud Carlos III, Madrid, Spain
Pacheco YM:
Laboratory of Immunology, Instituto de Biomedicina de Sevilla (IBiS)/UGC Clinical Laboratories, Hospital Universitario Virgen del Rocío, Sevilla, Spain
García M:
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
Blanco J:
IrsiCaixa AIDS Research Institute, Badalona, Spain
Medrano LM:
Instituto de Salud Carlos III, Madrid, Spain
Navarrete-Muñoz MA:
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
:
Hospital General Universitario de Elche & University Miguel Hernández, Alicante, Spain
Miralles P:
Hospital General Universitario Gregorio Marañón, Madrid, Spain
Dalmau D:
Hospital Universitari Mutua Terrasa, Terrasa, Spain
Gómez JL:
Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Górgolas M:
Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Cabello A:
Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Resino S:
Instituto de Salud Carlos III, Madrid, Spain
Benito JM:
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
Rallón N:
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
Green Submitted, Green Published, gold
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