Reduced risk of pancreatic cancer associated with asthma and nasal allergies
Por:
Gomez-Rubio P, Zock JP, Rava M, Marquez M, Sharp L, Hidalgo M, Carrato A, Ilzarbe L, Michalski C, Molero X, Farré A, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barbera V, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Muñoz-Bellvís L, Alvarez-Urturi C, Balcells J, Barneo L, Costello E, Guillén-Ponce C, Kleeff J, Kong B, Lawlor R, Löhr M, Mora J, Murray L, O'Driscoll D, Peláez P, Poves I, Scarpa A, Real FX, Malats N and PanGenEU Study Investigators
Publicada:
1 feb 2017
Categoría:
Gastroenterology
Resumen:
Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.
Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model.
Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk.
Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.
Filiaciones:
Gomez-Rubio P:
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Zock JP:
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Rava M:
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Marquez M:
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Sharp L:
National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UK
Hidalgo M:
Hospital Madrid-Norte-Sanchinarro, Madrid, Spain
Carrato A:
Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain
Ilzarbe L:
Hospital del Mar-Parc de Salut Mar, Barcelona, Spain
Michalski C:
Technical University of Munich, Munich, Germany
Molero X:
Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Farré A:
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Perea J:
Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain
Greenhalf W:
The Royal Liverpool University Hospital, Liverpool, UK
O'Rorke M:
Centre for Public Health, Queen's University Belfast, Belfast, UK
Tardón A:
Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
Gress T:
Department of Gastroenterology, University Hospital Giessen and Marburg, Marburg, Germany
Barbera V:
Laboratorio de Genética Molecular, Hospital General Universitario de Elche, Elche, Spain
Crnogorac-Jurcevic T:
Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
Domínguez-Muñoz E:
Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain
Muñoz-Bellvís L:
Cirugía General y del Aparato Digestivo, Hospital Universitario de Salamanca, Salamanca, Spain
Alvarez-Urturi C:
Hospital del Mar-Parc de Salut Mar, Barcelona, Spain
Balcells J:
Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Barneo L:
Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
Costello E:
The Royal Liverpool University Hospital, Liverpool, UK
Guillén-Ponce C:
Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain
Kleeff J:
Technical University of Munich, Munich, Germany
Kong B:
Technical University of Munich, Munich, Germany
Lawlor R:
Department of Pathology and Diagnostics, University of Verona, Verona, Italy
Löhr M:
Gastrocentrum, Karolinska Institutet, Stockholm, Sweden
Mora J:
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Murray L:
Centre for Public Health, Queen's University Belfast, Belfast, UK
O'Driscoll D:
National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UK
Peláez P:
Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain
Poves I:
Hospital del Mar-Parc de Salut Mar, Barcelona, Spain
Scarpa A:
Department of Pathology and Diagnostics, University of Verona, Verona, Italy
Real FX:
Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Malats N:
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain.
Green Submitted
|