The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin.


Por: Torijano-Gutiérrez S, Vilanova C, Díaz-Oltra S, Murga J, Falomir E, Carda M, Redondo-Horcajo M, Díaz JF, Barasoain I and Marco JA

Publicada: 1 ago 2015
Resumen:
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of the molecules on two reference tumoral cell lines were measured. In addition, the effects of the compounds on the cell cycle and on microtubule assembly were observed. The dynamics of microtubule polymerization was investigated by means of immunofluorescence assays. It was thus established that at least some of the compounds under study exert their cytotoxic action by means of interaction with tubulin.

Filiaciones:
Torijano-Gutiérrez S:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Vilanova C:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Díaz-Oltra S:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Murga J:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Carda M:
 Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Redondo-Horcajo M:
 CIB, CSIC, Madrid, Spain

Díaz JF:
 CIB, CSIC, Madrid, Spain

Barasoain I:
 CIB, CSIC, Madrid, Spain

Marco JA:
 Departamento de Química Orgánica, Universidad Valencia, Burjassot, Spain
ISSN: 15214184





ARCH PHARM
Editorial
John Wiley & Sons Ltd., Alemania
Tipo de documento: Article
Volumen: 348 Número: 8
Páginas: 541-547
WOS Id: 000358947200002
ID de PubMed: 26085125

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