Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk
Por:
Papandreou C, Babio N, Díaz-López A, Martínez-González MÁ, Becerra-Tomas N, Corella D, Schröder H, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez AJ, Serra-Majem L, Estruch R, Muñoz-Garach A, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, M Sánchez V, Vidal J, Vázquez C, Ros E, Ruiz-Canela M, Bulló M, Sorli JV, Quifer M, Colom A, Oncina-Canovas A, T Sierra L, Barón-López J, Pérez-Farinós N, Abete I, Sanchez-Villegas A, Casas R, F García JC, Santos-Lozano JM, Corbella E, Del M Bibiloni M, Diez-Espino J, Asensio EM, Torras L, Morey M, Compañ-Gabucio L, S Lete I, Cenoz-Osinaga JC, Castañer O and Salas-Salvadó J
Publicada:
1 abr 2019
Resumen:
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevencion con Dieta Mediterranea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( = -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio ( = -0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.
Filiaciones:
Papandreou C:
Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43201 Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007 Reus, Spain.
Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), InstituteofHealth Carlos III, 28029 Madrid, Spain.
University Hospital of Sant Joan de Reus, Nutrition Unit, 43204 Reus, Spain.
Martínez-González MÁ:
Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31009 Pamplona, Spain.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
:
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain.
Schröder H:
Cardiovascular Risk and Nutrition research group (CARIN), Hospital del Mar Research Institute (IMIM), 08003 Barcelona, Spain.
Romaguera D:
Clinical Epidemiology and Public Health Department, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Vioque J:
CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28009 Madrid, Spain.
Nutritional Epidemiology Unit, University of Miguel Hernández, Isabial-Fisabio, Alicante, Spain. Miguel Hernandez University, ISABIAL-FISABIO, 03202 Alicante, Spain.
Alonso-Gómez ÁM:
Department of Cardiology, Organización Sanitaria Integrada (OSI) ARABA, University Hospital Araba, 01009 Vitoria-Gasteiz, Spain.
Wärnberg J:
Department of Nursing, School of Health Sciences, University of Málaga-IBIMA, 29016 Málaga, Spain.
Martínez AJ:
Department of Nutrition, Food Science and Physiology, University of Navarra, IDISNA, 43204 Pamplona, Spain.
Serra-Majem L:
University of Las Palmas de Gran Canaria, Research Institute of Biomedical and Health Sciences (IUIBS), Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35001 Las Palmas, Spain.
Estruch R:
Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, 08007 Barcelona, Spain.
Muñoz-Garach A:
Virgen de la Victoria Hospital, Department of Endocrinology (IBIMA), University of Málaga, 29016 Málaga, Spain.
Lapetra J:
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41013 Sevilla, Spain.
Pintó X:
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, 08907 Barcelona, Spain.
Tur JA:
Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands & Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Garcia-Rios A:
Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain.
Bueno-Cavanillas A:
Department of Preventive Medicine, University of Granada, 18071 Granada, Spain.
Delgado-Rodríguez M:
Division of Preventive Medicine, Faculty of Medicine, University of Jaén, 23071 Jaén, Spain.
Matía-Martín P:
Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
Daimiel L:
Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain.
M Sánchez V:
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
Vidal J:
CIBER Diabetes y enfermedades Metabólicos (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
Endocrinology and Nutrition Department, Hospital Clinic Universitari, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Vázquez C:
Department of Endocrinology and Nutrition, University Hospital Fundación Jimenez Díaz, 28040 Madrid, Spain.
Ros E:
Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08007 Barcelona, Spain.
Oncina-Canovas A:
Miguel Hernandez University, ISABIAL-FISABIO, 03202 Alicante, Spain.
Barón-López J:
Department of Public Health, University of Málaga-IBIMA, 29016 Málaga, Spain.
Open Access
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