Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
Por:
Collado R, Ivars D, Oliver I, Tormos C, Egea M, Miguel A, Sáez GT and Carbonell F
Publicada:
1 ene 2014
Resumen:
Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2'-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.
Filiaciones:
Collado R:
Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain
:
Department of Medicine, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 13, 46010 Valencia, Spain
Oliver I:
Department of Medicine, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 13, 46010 Valencia, Spain
Tormos C:
CIBERobn, Biomedical Network Research Centre in Physiopathology of Obesity and Nutrition, Choupana s/n, 15706 Santiago de Compostela, Spain
Egea M:
Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain
Miguel A:
Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain
:
CIBERobn, Biomedical Network Research Centre in Physiopathology of Obesity and Nutrition, Choupana s/n, 15706 Santiago de Compostela, Spain
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 13, 46010 Valencia, Spain
Service of Clinical Analyses, CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain
Carbonell F:
Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain
Department of Medicine, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 13, 46010 Valencia, Spain
Gold, Green Published
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