Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population-based study
Por:
Galan-Chilet I, Tellez-Plaza M, Guallar E, De Marco G, Lopez-Izquierdo R, Gonzalez-Manzano I, Carmen Tormos M, Martin-Nuñez GM, Rojo-Martinez G, Saez GT, Martín-Escudero JC, Redon J and Javier Chaves F
Publicada:
1 sep 2014
Resumen:
The role of selenium exposure in preventing chronic disease is controversial, especially in selenium-repleted populations. At high concentrations, selenium exposure may increase oxidative stress. Studies evaluating the interaction of genetic variation in genes involved in oxidative stress pathways and selenium are scarce. We evaluated the cross-sectional association of plasma selenium concentrations with oxidative stress levels, measured as oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine (8-oxo-dG) in urine, and the interacting role of genetic variation in oxidative stress candidate genes, in a representative sample of 1445 men and women aged 18-85 years from Spain. The geometric mean of plasma selenium levels in the study sample was 84.76 mu g/L. In fully adjusted models the geometric mean ratios for oxidative stress biomarker levels comparing the highest to the lowest quintiles of plasma selenium levels were 0.61 (0.50-0.76) for GSSG/GSH, 0.89 (0.79-1.00) for MDA, and 1.06 (0.96-1.18) for 8-oxo-dG. We observed nonlinear dose-responses of selenium exposure and oxidative stress biomarkers, with plasma selenium concentrations above similar to 110 mu g/L being positively associated with 8-oxo-dG, but inversely associated with GSSG/GSH and MDA. In addition, we identified potential risk genotypes associated with increased levels of oxidative stress markers with high selenium levels. Our findings support that high selenium levels increase oxidative stress in some biological processes. More studies are needed to disentangle the complexity of selenium biology and the relevance of potential gene-selenium interactions in relation to health outcomes in human populations. (C) 2014 Elsevier Inc. All rights reserved.
Filiaciones:
Galan-Chilet I:
Genotyping and Genetic Diagnosis Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain
Tellez-Plaza M:
Area of Cardiometabolic and Renal Risk, Institute for Biomedical Research INCLIVA, Valencia, Spain
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Guallar E:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Department of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
De Marco G:
Genotyping and Genetic Diagnosis Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain
Lopez-Izquierdo R:
Department of Internal Medicine, Hospital Universitario Rio Hortega, Valladolid, Spain
Gonzalez-Manzano I:
Department of Internal Medicine, Hospital Universitario Rio Hortega, Valladolid, Spain
Carmen Tormos M:
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Minister of Health, Madrid, Spain
Martin-Nuñez GM:
Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Hospital Regional Universitario de Malaga, Malaga, Spain
CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain
Rojo-Martinez G:
Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Hospital Regional Universitario de Malaga, Malaga, Spain
:
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Minister of Health, Madrid, Spain
Department of Biochemistry and Molecular Biology, School of Medicine, University of Valencia, Spain
Service of Clinical Analysis-CDBI
Hospital General Universitario de Valencia (HGUV) Valencia, Spain
Martín-Escudero JC:
Department of Internal Medicine, Hospital Universitario Rio Hortega, Valladolid, Spain
Redon J:
Area of Cardiometabolic and Renal Risk, Institute for Biomedical Research INCLIVA, Valencia, Spain
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Minister of Health, Madrid, Spain
Department of Internal Medicine, Hospital Clínico de Valencia, Valencia, Spain
Javier Chaves F:
Genotyping and Genetic Diagnosis Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain
CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain
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