Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach
Por:
Flores-Mateo G, Elosua R, Rodriguez-Blanco T, Basora-Gallisà J, Bulló M, Salas-Salvadó J, Martínez-González MÁ, Estruch R, Corella D, Fitó M, Fiol M, Arós F, Gómez-Gracia E, Subirana I, Lapetra J, Ruiz-Gutiérrez V, Sáez GT and Covas MI
Publicada:
30 sep 2014
Resumen:
Background: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients.
Methods: We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvencion con DIeta MEDiterranea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures.
Results: Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance = 1013.5; P < 0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively).
Conclusion: In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population.
Filiaciones:
Flores-Mateo G:
Unitat de Suport a la Recerca Tarragona-Reus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Tarragona, Spain
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Elosua R:
Epidemiology and Cardiovascular Genetics Research Group, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Rodriguez-Blanco T:
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain
Basora-Gallisà J:
Unitat de Suport a la Recerca Tarragona-Reus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Tarragona, Spain
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Bulló M:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain
Salas-Salvadó J:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain
Martínez-González MÁ:
Department of Preventive Medicine and Public Health, University of Navarra-Osasunbidea, Servicio Navarro de Salud, Pamplona, Spain
Estruch R:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Internal Medicine, Hospital Clinic, Institut dInvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain
Corella D:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
Fitó M:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
Fiol M:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Institute for Health Sciences Investigation, IdISPa, Palma de Mallorca, Spain
Arós F:
Department of Cardiology, Hospital Txangorritxu, Vitoria, Spain
Gómez-Gracia E:
Department of Epidemiology, School of Medicine of Malaga, Malaga, Spain
Subirana I:
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain
Lapetra J:
Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain
Ruiz-Gutiérrez V:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Instituto de la Grasa, CSIC, Sevilla, Spain
:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Service of Clinical Analysis, Doctor Peset University Hospital, University of Valencia, Valencia, Spain
Covas MI:
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
Green Published, gold, Green Submitted
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