The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls
Por:
Ata B, Yildiz S, Turkgeldi E, Brocal VP, Dinleyici EC, Moya A and Urman B
Publicada:
18 feb 2019
Ahead of Print:
18 feb 2019
Categoría:
Multidisciplinary
Resumen:
Dysbiosis in the genital tract or gut microbiome can be associated with endometriosis. We sampled vaginal, cervical and gut microbiota from 14 women with histology proven stage 3/4 endometriosis and 14 healthy controls. The V3 and V4 regions of the 16S rRNA gene were amplified following the 16S Metagenomic Sequencing Library Preparation. Despite overall similar vaginal, cervical and intestinal microbiota composition between stage 3/4 endometriosis group and controls, we observed differences at genus level. The complete absence of Atopobium in the vaginal and cervical microbiota of the stage 3/4 endometriosis group was noteworthy. In the cervical microbiota, Gardnerella, Streptococcus, Escherichia, Shigella, and Ureoplasma, all of which contain potentially pathogenic species, were increased in stage 3/4 endometriosis. More women in the stage 3/4 endometriosis group had Shigella/Escherichia dominant stool microbiome. Further studies can clarify whether the association is causal, and whether dysbiosis leads to endometriosis or endometriosis leads to dysbiosis.
Filiaciones:
Ata B:
Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, Istanbul, Turkey.
Yildiz S:
Department of Obstetrics and Gynecology, Koc University Hospital, Istanbul, Turkey
Turkgeldi E:
Department of Obstetrics and Gynecology, Koc University Hospital, Istanbul, Turkey
:
Área de Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública), Valencia, Spain
Dinleyici EC:
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey
:
Área de Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública), Valencia, Spain
Institute for Integrative Systems Biology, Universitat de València, Valencia, Spain
CIBER en Epidemiología y Salud Pública (CIBEResp), Madrid, Spain
Urman B:
Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, Istanbul, Turkey
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