Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Por:
Forns, J, Lertxundi, N, Aranbarri, A, Murcia, M, Gascon, M, Martinez, D, Grellier, J, Lertxundi, A, Julvez, J, Fano, E, Goni, F, Grimalt, J, Ballester, F, Sunyer, J and Ibarluzea, J
Publicada:
15 sep 2012
Categoría:
Environmental Science (miscellaneous)
Resumen:
Polychlorinated biphenyls (PCB), hexachlorobenzene (HCB). and dichlorodiphenyl dichloroethylene (pp'DDE) are persistent, bioaccumulative, and toxic environmental pollutants with potential neurotoxic effects. Despite a growing body of studies investigating the health effects associated with these compounds, their specific effects on early neuropsychological development remain unclear. We investigated such neuropsychological effects in a population-based birth cohort based in three regions in Spain (Sabadell, Gipuzkoa, and Valencia) derived from the INMA [Environment and Childhood] Project. The main analyses in this report were based on 1391 mother-child pairs with complete information on maternal levels of organochlorine compounds and child neuropsychological assessment (Bayley Scales of Infant Development) at age 14 months. We found that prenatal PCB exposure, particularly to congeners 138 and 153, resulted in impairment of psychomotor development (coefficient= - 1.24, 95% confidence interval = - 2.41. - 0.07), but found no evidence for effects on cognitive development. Prenatal exposure to pp'DDE or HCB was not associated with early neuropsychological development. The negative effects of exposure to PCBs on early psychomotor development suggest that the potential neurotoxic effects of these compounds may be evident even at low doses. (c) 2012 Elsevier Ltd. Al! rights reserved.
Filiaciones:
Forns, J:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Lertxundi, N:
Univ Basque Country UPV EHU, Fac Psychol, Donostia San Sebastian, Spain
Hlth Res Inst, Donostia San Sebastian, Spain
Aranbarri, A:
Univ Basque Country UPV EHU, Fac Psychol, Donostia San Sebastian, Spain
Hlth Res Inst, Donostia San Sebastian, Spain
:
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Ctr Publ Hlth Res CSISP, Valencia, Spain
Gascon, M:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Martinez, D:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Grellier, J:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England
Lertxundi, A:
Hlth Res Inst, Donostia San Sebastian, Spain
Univ Basque Country, Fac Med & Dent, San Sebastian, Spain
Julvez, J:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
Fano, E:
Univ Basque Country UPV EHU, Fac Psychol, Donostia San Sebastian, Spain
Hlth Res Inst, Donostia San Sebastian, Spain
Goni, F:
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Lab Salud Publ Guipuzcoa, San Sebastian, Spain
Grimalt, J:
Inst Environm Assessment & Water Res IDAEA CSIC, Dept Environm Chem, Barcelona, Spain
:
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Ctr Publ Hlth Res CSISP, Valencia, Spain
Univ Valencia, Valencia, Spain
Sunyer, J:
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Hosp Mar Res Inst IMIM, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Pompeu Fabra Univ, Barcelona, Spain
Ibarluzea, J:
Hlth Res Inst, Donostia San Sebastian, Spain
Basque Govt Hlth Dept, Subdirecc Salud Publ Gipuzkoa, San Sebastian, Spain
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