Influence of atrial fibrillation on the mortality of patients with heart failure with preserved ejection fraction


Por: Franco J, Formiga F, Cepeda J, Llacer P, Arévalo-Lorido J, Cerqueiro J, González-Franco A, Epelde F, Manzano L and Montero Pérez-Barquero M

Publicada: 23 may 2018
Categoría: Medicine (miscellaneous)

Resumen:
Introduction and objectives: The impact of atrial fibrillation (AF) on the prognosis of heart failure with preserved ejection fraction (HFpEF) is still the subject of debate. We analysed the influence of AF on the prognosis on mortality and readmission in patients with HFpEF. Methods: Prospective observational study in 1,971 patients with HFpEF, who were admitted for acute heart failure. Patients were divided into 2 groups according to the presence or absence of AF. We analysed mortality, readmissions and combined mortality/readmissions at one year follow-up. Results: A total of 1,177 (59%) patients had AF, mean age 80.3 (7.8) years and 1,233 (63%) were women. Patients with HFpEF and AF were older, female, greater valvular aetiology and lower comorbidity measured by the Charlson index. At the one year follow-up, 430 (22%) patients had died and 840 (43%) had been readmitted. In the 2 groups analysed, there was no difference in all-cause mortality (22 vs. 21%; P= .739, AF vs. no-AF, respectively) or cardiovascular causes (9.6 vs. 8.2%; P = .739, AF vs. no-AF, respectively). In the multivariable analysis, factors associated with higher mortality were: age, male, valvular aetiology, uric acid, and comorbidity. In the analysis of the subgroup with HFpEF with AF, the presence of chronic AF compared to de novo AF was associated with higher mortality (HR 1,716; 95% CI 1,099-2,681; P = .018). Conclusions: In patients with HFpEF, the presence of AF is frequent. During the one-year follow-up, the presence of AF does not influence mortality or readmissions in patients with HFpEF. (C) 2017 Elsevier Espana, S.L.U. All rights reserved.

Filiaciones:
Franco J:
 Servicio de Medicina Interna, Hospital Universitario Quirón Dexeus, Barcelona, España

Formiga F:
 Programa de Geriatría, Servicio de Medicina Interna, Hospital Universitari de Bellvitge, Institut d'Investigació Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España

:
 Servicio de Medicina Interna, Hospital Vega Baja, Orihuela, Alicante, España

Llacer P:
 Servicio de Medicina Interna, Hospital de Manises, Manises, Valencia, España

Arévalo-Lorido J:
 Servicio de Medicina Interna, Hospital Comarcal de Zafra, Zafra, Badajoz, España

Cerqueiro J:
 Servicio de Medicina Interna, Hospital Universitario Lucus Augusti, Lugo, España

González-Franco A:
 Servicio de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Asturias, España

Epelde F:
 Servicio de Medicina Interna, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España

Manzano L:
 Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España

Montero Pérez-Barquero M:
 Servicio de Medicina Interna, Hospital Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba, España
ISSN: 00257753





MEDICINA CLINICA
Editorial
ELSEVIER DOYMA SL, TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN, España
Tipo de documento: Article
Volumen: 150 Número: 10
Páginas: 376-382
WOS Id: 000439254300002
ID de PubMed: 28870424

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