LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients
Por:
Castellví I, Eguiluz S, Escudero-Contreras A, Ríos JJ, Calvo-Alén J, Callejas-Rubio JL, De la Puente C, Simeón CP, Narváez FJ, Espinosa G, Carreira PE, Rubio-Rivas M, Alegre JJ, Guillén-Del-Castillo A, Román-Ivorra JA and Fonollosa V
Publicada:
1 nov 2019
Ahead of Print:
14 sep 2019
Resumen:
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58 years; p < 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p < 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p < 0.013), eat (p < 0.013) and grip (p < 0.03), and higher Visual Analogic Scale scores for pain (p < 0.013), trouble related with Raynaud's Phenomenon (p < 0.001) and sense of severity (p < 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.
Filiaciones:
Castellví I:
Unitat de Reumatologia, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08026, Barcelona, Spain.
Eguiluz S:
Servicio de Medicina Interna, Hospital Universitario de Cruces, Barakaldo, Spain
Escudero-Contreras A:
Unidad de Gestión Clínica de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain
Ríos JJ:
Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain
Calvo-Alén J:
Servicio de Reumatología, Hospital Universitario Araba, Vitoria, Spain
Callejas-Rubio JL:
Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario San Cecilio, Granada, Spain
De la Puente C:
Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
Simeón CP:
Unitat de Malalties Autoimmunes Sistèmicas, Servei de Medicina Interna, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Narváez FJ:
Servei de Reumatologia, Hospital Universitari de Bellvitge, Barcelona, Spain
Espinosa G:
Servei de Medicina Interna, Hospital Clínic de Barcelona, Barcelona, Spain
Carreira PE:
Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, Spain
Rubio-Rivas M:
Unitat de Malalties Autoimmunes, Servei de Medicina Interna, Hospital Universitari de Bellvitge, Barcelona, Spain
:
Servei de Reumatologia, Hospital Universitari Dr. Peset, València, Spain
Guillén-Del-Castillo A:
Unitat de Malalties Autoimmunes Sistèmicas, Servei de Medicina Interna, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Román-Ivorra JA:
Servei de Reumatologia, Hospital Universitari i Politècnic la Fe, Universitat Catòlica de València, València, Spain
Fonollosa V:
Unitat de Malalties Autoimmunes Sistèmicas, Servei de Medicina Interna, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Hosp Univ La Paz, Serv Med Interna, Madrid, Spain.
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