Are the Spanish baseline series markers sufficient to detect contact allergy to corticosteroids in Spain? A GEIDAC prospective study
Por:
Mercader-García P, Pastor-Nieto MA, García-Doval I, Giménez-Arnau A, González-Pérez R, Fernández-Redondo V, Serra-Baldrich E, Cordoba-Guijarro S, Gatica-Ortega ME, Silvestre J and GEIDAC¶
Publicada:
1 ene 2018
Resumen:
Background. Corticosteroids are among the most commonly used topical
drugs. Contact allergy to these exists, but can be easily missed.
Corticosteroid screening markers have been included in the baseline
series with the aim of detecting most of the sensitized patients.
Objectives. To assess the prevalence of contact allergy to topical
corticosteroids in Spain and examine the usefulness of corticosteroid
markers to detect contact allergy to corticosteroids.
Methods. In total, 3699 patients referred to 20 dermatology departments
across Spain for patch testing with the baseline series, including
budesonide and tixocortol pivalate, were also tested with six
supplementary corticosteroids (methylprednisolone aceponate, mometasone
furoate, prednicarbate, clobetasol propionate, betamethasone
17-valerate, and betamethasone 17,21-dipropionate). Additionally, 2547
(68.8%) patients were tested with hydrocortisone 17-butyrate.
Results. Fifty-four patients showed positive reactions to at least one
of all tested corticosteroids (1.46%). Thirty-nine (1.05%) reacted to at
least one of the additionally tested corticosteroids; among these, 24 of
39 (61.5%) did not react to any of the corticosteroid allergy screening
markers tested.
Conclusions. More than half of the patients who were allergic to the
additionally tested corticosteroids were not detected with the
corticosteroid allergy markers. An update of the corticosteroid allergy
screening markers is encouraged, with consideration of group 3
corticosteroids.
Filiaciones:
Mercader-García P:
Dermatology Department, Hospital General Universitario Jose Mª Morales Meseguer, 30008, Murcia, Spain
Pastor-Nieto MA:
Dermatology Department, Hospital Universitario de Guadalajara, 19002, Guadalajara, Spain
García-Doval I:
Unidad de Investigación of the Fundación Piel Sana AEDV of the Spanish Academy of Dermatology, 28008, Madrid, Spain
Giménez-Arnau A:
Dermatology Department, Hospital del Mar, 08003, Barcelona, Spain
González-Pérez R:
Dermatology Department, Hospital Universitario de Araba, 01009, Vitoria-Gasteiz, Spain
Fernández-Redondo V:
Dermatology Deparment, Hospital Gil-Casares, 15706, Santiago de Compostela, Spain
Serra-Baldrich E:
Dermatology Deparment, Hospital Sant Pau, 08025, Barcelona, Spain
Cordoba-Guijarro S:
Dermatology Deparment, Hospital Universitario de Fuenlabrada, 28942, Madrid, Spain
Gatica-Ortega ME:
Dermatology Deparment, Complejo Hospitalario Virgen del Valle, 45071, Toledo, Spain
Silvestre J:
Dermatology Department, Hospital General de Alicante, 03010, Alicante, Spain
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