Anti-Anisakis sp antibodies in serum of patients with sepsis and their relationship with gamma delta T cells and disease severity
Por:
Andreu-Ballester JC, Zamora V, Garcia-Ballesteros C, Benet-Campos C, Lopez-Chuliá F, Tormo-Calandín C and Cuéllar C
Publicada:
1 may 2018
Resumen:
Immunosuppression in sepsis reduces both alpha beta and gamma delta T cell subsets. Anisakis sp. is a parasitic nematode with a high prevalence in Spain. Previous contact with the parasite is related to a decrease in gamma delta T cells. Anti-Anisakis antibodies were measured and related to alpha beta and gamma delta T cells in 114 septic patients versus 97 healthy controls. Significant differences were seen with respect to the groups with severe sepsis and septic shock where lower anti-Anisakis levels were observed. A similar decrease appeared in the case of specific IgM with significant differences between the groups of control/uncomplicated sepsis versus severe sepsis and septic shock. These differences were also apparent in the case of specific IgA. The lowest IgE levels were detected in the septic shock group. Anti-Anisakis IgG levels significantly increased in septic shock groups compared with the controls. We observed positive correlations among anti-Anisakis IgA levels and all gamma delta T cell subsets. There were negative correlations among IgA levels and APACHE and SOFA indices. Greater contact with the parasite (IgG) was directly related with septic shock, inflammation and markers of sepsis severity. A lack of protection in the mucosa (IgA and gamma delta T cells) was associated with the disease severity. (C) 2018 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
:
Departamento de Investigación, Hospital Arnau de Vilanova, 46015 Valencia, Spain
Zamora V:
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
:
Servicio de Hematología, Hospital Arnau de Vilanova, 46015 Valencia, Spain
:
Servicio de Hematología, Hospital Arnau de Vilanova, 46015 Valencia, Spain
:
Servicio de Hematología, Hospital Arnau de Vilanova, 46015 Valencia, Spain
Tormo-Calandín C:
Facultad de Medicina, Universidad Católica, 46001 Valencia, Spain
Cuéllar C:
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
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