Domain-specific patterns of physical activity and risk of breast cancer sub-types in the MCC-Spain study
Por:
Huerta JM, Molina AJ, Chirlaque MD, Yepes P, Moratalla-Navarro F, Moreno V, Amiano P, Guevara M, Moreno-Iribas C, Llorca J, Fernández-Tardón G, Molina-Barcelo, A, Alguacil J, Marcos-Gragera R, Castaño-Vinyals G, Pérez-Gómez B, Kogevinas M, Pollán M and Martín V
Publicada:
1 oct 2019
Ahead of Print:
17 jul 2019
Resumen:
Purpose Literature on the separate effects of physical activities (PA) on risk of breast cancer (BC) sub-types is heterogeneous. We investigated domain-specific associations between PA and BC risk by menopausal status and molecular subtype. Methods 1389 histologically confirmed invasive BC cases and 1712 controls from the MCC-Spain study were included (age: 20-85 years). Questionnaire information on PA at work, at home, and during leisure time, including recreational PA and sedentary time, and data on reproductive history, anthropometry, family history of BC, diet, and lifestyles were obtained through face-to-face interviews. Information on the expression of oestrogen (ER), progesterone (PR), and HER2 receptors was available for > 95% of the cases. Mixed-effects multivariable logistic regression models were used to estimate odds ratios (OR) of BC sub-types. Results Occupational PA (OPA) intensity was associated with higher BC risk. Associations were stronger for pre-menopausal (ORactive/very active vs. sedentary job 1.89; 95% confidence interval (CI) 1.22, 2.91) and ER+/PR+, HER2- tumours (OR 1.80; 95% CI 1.28, 2.53). Sedentary time was associated with higher risk of post-menopausal BC (OR6-9 vs. <3 h/day 1.69; 95% CI 1.22, 2.32). Moderate-to-high-intensity household (HPA) and recreational PA (RPA) were inversely associated with BC occurrence in pre- and post-menopausal women, with estimated 14-33% lower risks (P for trend < 0.001) above 1000 MET center dot min/week. Conclusions Higher levels of HPA and RPA were associated with lower risk of BC, with heterogeneity by molecular type, whereas sitting time was a consistent independent risk factor of BC risk. The positive association found for OPA with ER+/PR+ BC deserves further investigation.
Filiaciones:
Huerta JM:
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Ronda de Levante 11, 30008, Murcia, Spain
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Molina AJ:
Grupo de Investigación en Interacciones Gen-Ambiente Y Salud (GIIGAS), Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana, s/n, 24071, León, Spain.
Área de Medicina Preventiva y Salud Pública. Departamento de Ciencias Biomédicas, Universidad de León, Campus de Vegazana, s/n, 24071, León, Spain.
Chirlaque MD:
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Ronda de Levante 11, 30008, Murcia, Spain
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Departamento de Ciencias Sociosanitarias, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain
Yepes P:
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Ronda de Levante 11, 30008, Murcia, Spain
Moratalla-Navarro F:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology and Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran Via de L'Hospitalet, 199, 08908, Hospitalet de Llobregat, Spain
Moreno V:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology and Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran Via de L'Hospitalet, 199, 08908, Hospitalet de Llobregat, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Feixa Llarga, s/n, 08907, Hospitalet de Llobregat, Spain
Amiano P:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Public Health Division of Gipuzkoa, Biodonostia Research Institute, Avda. de Navarra, 4, 20013, Donostia-San Sebastián, Spain
Guevara M:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Navarra Public Health Institute, Calle Leyre, 15, 31003, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, C/ Irunlarrea, 3, 31008, Pamplona, Spain
Moreno-Iribas C:
Navarra Public Health Institute, Calle Leyre, 15, 31003, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, C/ Irunlarrea, 3, 31008, Pamplona, Spain
REDISSEC, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Madrid, Spain
Llorca J:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Facultad de Medicina, Universidad de Cantabria, Av. Cardenal Herrera Oria, s/n, 39011, Santander, Spain
Fernández-Tardón G:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Instituto Universitario de Oncología, Universidad de Oviedo, C/ Julián Clavería, s/n, 33006, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011, Oviedo, Spain
:
Cancer and Public Health Area, FISABIO-Public Health, Avda. de Catalunya, 21, 46020, Valencia, Spain
Alguacil J:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Centro de Investigación en Recursos Naturales, Salud Y Medio Ambiente (RENSMA), Universidad de Huelva, Avda. de Las Fuerzas Armadas, s/n, 21007, Huelva, Spain
Marcos-Gragera R:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Epidemiology Unit and Girona Cancer Registry. Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Av. França, s/n, 17007, Girona, Spain
Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), C/ Dr. Castany, s/n, 17190, Salt, Spain
Castaño-Vinyals G:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
ISGlobal, C/ Rosselló, 132, 08036, Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), C/ Doctor Aiguader, 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaza de La Merced, 10, 08002, Barcelona, Spain
Pérez-Gómez B:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Environmental and Cancer Epidemiology Department, National Centre of Epidemiology-Instituto de Salud Carlos III, C/ Melchor Fernández Almagro, 5, 28029, Madrid, Spain
Oncology and Hematology Area, IIS Puerta De Hierro, Cancer Epidemiology Research Group, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain
Kogevinas M:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
ISGlobal, C/ Rosselló, 132, 08036, Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), C/ Doctor Aiguader, 88, 08003, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Plaza de La Merced, 10, 08002, Barcelona, Spain
Pollán M:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Environmental and Cancer Epidemiology Department, National Centre of Epidemiology-Instituto de Salud Carlos III, C/ Melchor Fernández Almagro, 5, 28029, Madrid, Spain
Oncology and Hematology Area, IIS Puerta De Hierro, Cancer Epidemiology Research Group, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain
Martín V:
CIBER Epidemiología Y Salud Pública (CIBERESP), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain
Grupo de Investigación en Interacciones Gen-Ambiente Y Salud (GIIGAS), Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana, s/n, 24071, León, Spain
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