Associations of black carbon with lung function and airway inflammation in schoolchildren
Por:
Paunescu, A, Casas, M, Ferrero, A, Pañella P, Bougas, N, Beydon, N, Just, J, Lezmi, G, Sunyer, J, Ballester, F and Momas, I
Publicada:
1 oct 2019
Ahead of Print:
10 jul 2019
Categoría:
Environmental science (miscellaneous)
Resumen:
Background: Few studies have investigated the 24-hour respiratory health effects of personal black carbon (BC) and ultrafine particles (UFP) exposure in schoolchildren. The objective of this study was to investigate these associations with the lung function in children 10-years old with and without persistent respiratory symptoms.
Methods: We conducted a cross-sectional study in 305 children (147 and 158 with and without persistent respiratory symptoms, respectively) from three European birth-cohorts: PARIS (France) and INMA Sabadell and Valencia (Spain). Personal 24-hour measurements of exposure concentrations to BC and UFP were performed by portable devices, before lung function testing. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and the fraction of exhaled nitric oxide (FeNO) were determined.
Results: There was no association of UFP with lung function parameters or FeNO whereas the increase in 24-hour BC exposure concentrations was related to a statistically significant decrease in lung function parameters only among children with persistent respiratory symptoms [ - 96.8 mL (95% Confidence Interval CI: - 184.4 to - 9.1 mL) in FVC, and -107.2 mL (95% CI: -177.5 to - 36.9 mL) in FEV1 for an inter-quartile range of 1160 ng/m(3) exposure increase]. A significant positive association between BC and FeNO was observed only in children with persistent respiratory symptoms with current wheezing and/or medication to improve breathing [FeNO increases with + 6.9 ppb (95% CI: 0.7 to 13.1 ppb) with an inter-quartile range BC exposure increase].
Conclusion: Children suffering from persistent respiratory symptoms appear to be more vulnerable to BC exposure.
Filiaciones:
Paunescu, A:
Inserm U1153-CRESS HERA Team, Faculté de Pharmacie de Paris, Université Paris Descartes, France
Casas, M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain
:
CIBER Epidemiología y Salud Pública (CIBERESP), Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Spain
Pañella P:
ISGlobal, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain
Bougas, N:
Inserm U1153-CRESS HERA Team, Faculté de Pharmacie de Paris, Université Paris Descartes, France
Beydon, N:
Unité Fonctionnelle de Physiologie - Explorations Fonctionnelles Respiratoires, AP-HP, Hôpital d'Enfants Armand-Trousseau, Paris, France
Just, J:
Service d'Allergologie Pédiatrique, AP-HP, Hôpital d'Enfants Armand-Trousseau, Paris, France
Lezmi, G:
Service de Pneumologie et d'Allergologie Pédiatriques, AP-HP, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France
Sunyer, J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain
:
CIBER Epidemiología y Salud Pública (CIBERESP), Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Spain
School of Nursing, University of Valencia, Spain
Momas, I:
Inserm U1153-CRESS HERA Team, Faculté de Pharmacie de Paris, Université Paris Descartes, France
Ville de Paris, Direction de l'Action Sociale, de l'Enfance et de la Santé, Cellule Cohorte PARIS, Paris, France
Green Published, gold
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