Factors Associated With Bronchiectasis in Patients With COPD
Por:
Martínez-García MÁ, Soler-Cataluña JJ, Donat Sanz Y, Catalán Serra P, Agramunt Lerma M, Ballestín Vicente J and Perpiñá-Tordera M
Publicada:
1 nov 2011
Resumen:
Background: Previous studies have shown a high prevalence of bronchiectasis in patients with moderate to severe COPD. However, the factors associated with bronchiectasis remain unknown in these patients. The objective of this study is to identify the factors associated with bronchiectasis in patients with moderate to severe COPD.
Methods: Consecutive patients with moderate (50% < FEV1 <= 70%) or severe (FEV1 <= 50%) COPD were included prospectively. All subjects filled out a clinical questionnaire, including information about exacerbations. Peripheral blood samples were obtained, and lung function tests were performed in all patients. Sputum samples were provided for monthly microbiologic analysis for 6 months. All the tests were performed in a stable phase for at least 6 weeks. High-resolution CT scans of the chest were used to diagnose bronchiectasis.
Results: Ninety-two patients, 51 with severe COPD, were included. Bronchiectasis was present in 53 patients (57.6%). The variables independently associated with the presence of bronchiectasis were severe airflow obstruction (OR, 3.87; 95% CI, 1.38-10.5; P = .001), isolation of a potentially pathogenic microorganism (PPM) (OR, 3.59; 95% CI, 1.3-9.9; P = .014), and at least one hospital admission due to COPD exacerbations in the previous year (OR, 3.07; 95% CI, 1.07-8.77; P = .037).
Conclusion: We found an elevated prevalence of bronchiectasis in patients with moderate to severe COPD, and this was associated with severe airflow obstruction, isolation of a PPM from sputum, and at least one hospital admission for exacerbations in the previous year. CHEST 2011; 140(5):1130-1137
Filiaciones:
:
Pneumology Unit, Requena General Hospital
CIBER de enfermedades respiratorias, Valencia, Spain
:
Pneumology Unit, Requena General Hospital
:
Service of Internal Medicine, Requena General Hospital
:
Pneumology Unit, Requena General Hospital
Agramunt Lerma M:
Radiology Department, Requena General Hospital
:
Radiology Department, Requena General Hospital
Perpiñá-Tordera M:
Service of Pneumology, La Fe University Hospital, Valencia, Spain
|