Clinical Application of the COPD Assessment Test Longitudinal Data From the COPD History Assessment in Spain (CHAIN) Cohort
Por:
de Torres JP, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Calle-Rubio M, Solanes-García I, Agüero Balbin R, de Diego-Damia A, Feu-Collado N, Alfageme Michavila I, Irigaray R, Balcells E, Llunell Casanovas A, Galdiz Iturri JB, Marín Royo M, Soler-Cataluña JJ, Lopez-Campos JL, Soriano JB, Casanova C and COPD History Assessment in Spain (CHAIN) Cohort*
Publicada:
1 jul 2014
Resumen:
OBJECTIVE: The COPD Assessment Test (CAT) has been proposed for assessing health status in COPD, but little is known about its longitudinal changes. The objective of this study was to evaluate 1-year CAT variability in patients with stable COPD and to relate its variations to changes in other disease markers.
METHODS: We evaluated the following variables in smokers with and without COPD at baseline and after 1 year: CAT score, age, sex, smoking status, pack-year history, BMI, modified Medical Research Council (mMRC) scale, 6-min walk distance (6MWD), lung function, BODE (BMI, obstruction, dyspnea, exercise capacity) index, hospital admissions, Hospital and Depression Scale, and the Charlson comorbidity index. In patients with COPD, we explored the association of CAT scores and 1-year changes in the studied parameters.
RESULTS: A total of 824 smokers with COPD and 126 without COPD were evaluated at baseline and 441 smokers with COPD and 66 without COPD 1 year later. At 1 year, CAT scores for patients with COPD were similar (+/- 4 points) in 56%, higher in 27%, and lower in 17%. Of note, mMRC scale scores were similar (+/- 1 point) in 46% of patients, worse in 36%, and better in 18% at 1 year. One-year CAT changes were best predicted by changes in mMRC scale scores (beta-coefficient, 0.47; P < .001). Similar results were found for CAT and mMRC scale score in smokers without COPD.
CONCLUSIONS: One-year longitudinal data show variability in CAT scores among patients with stable COPD similar to mMRC scale score, which is the best predictor of 1-year CAT changes. Further longitudinal studies should confirm long-term CAT variability and its clinical applicability.
Filiaciones:
de Torres JP:
Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain
Marin JM:
Pulmonary Department, Hospital Universitario Miguel Servet, Zaragoza, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Martinez-Gonzalez C:
Pulmonary Department, Hospital Central de Asturias, Oviedo, Spain
de Lucas-Ramos P:
Pulmonary Department I, Hospital Gregorio Marañon, Madrid, Spain
Mir-Viladrich I:
Pulmonary Department, Hospital Son Llátzer, Palma de Mallorca, Madrid, Spain
Cosio B:
Pulmonary Department, Hospital Son Espases, Palma de Mallorca, Madrid, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Peces-Barba G:
Pulmonary Department, Fundación Jimenez Diaz, Madrid, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Calle-Rubio M:
Pulmonary Department, Hospital Clinico San Carlos, Madrid, Spain
Solanes-García I:
Pulmonary Department, Hospital San Pablo y la Santa Cruz, Barcelona, Spain
Agüero Balbin R:
Pulmonary Department, Hospital Marques de Valdecilla, Santander, Spain
de Diego-Damia A:
Pulmonary Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Feu-Collado N:
Pulmonary Department, Hospital Universitario Reina Sofía, Cordoba, Spain
Alfageme Michavila I:
Pulmonary Department, Hospital Universitario de Valme, Sevilla, Spain
Irigaray R:
Pulmonary Department, Hospital de Manacor, Mallorca, Spain
Balcells E:
Pulmonary Department, Hospital del Mar, Barcelona, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Llunell Casanovas A:
Pulmonary Department, Hospital de Terrassa, Terrassa, Spain
Galdiz Iturri JB:
Pulmonary Department, Hospital de Cruces, UPV/EHU, Bilbao, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
:
Pulmonary Department, Hospital General de Castellón, Castellón, Spain
:
Pulmonary Department, Hospital General de Requena, Valencia, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Lopez-Campos JL:
Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, Sevilla, Spain
CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
Soriano JB:
Epidemiology and Clinical Research, CIMERA, Bunyola, Mallorca, Spain
Casanova C:
Pulmonary Department, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain
Green Published, Green Submitted
|