Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
Por:
Fuertes A, Pérez-Burillo S, Apaolaza I, Vallès Y, Francino MP, Rufián-Henares JÁ and Planes FJ
Publicada:
24 abr 2019
Resumen:
Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.
Filiaciones:
Fuertes A:
Bioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, Spain
Bioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, Spain
Pérez-Burillo S:
Departamento de Nutrición y Bromatología, Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain
Apaolaza I:
Bioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, Spain
Bioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, Spain
Vallès Y:
Unitat Mixta d'Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-Salud Pública/Instituto de Biología Integrativa de Sistemas, Universitat de València, Valencia, Spain
Department of Biological and Chemical Sciences, The University of the West Indies, Cave Hill, Barbados
:
Unitat Mixta d'Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-Salud Pública/Instituto de Biología Integrativa de Sistemas, Universitat de València, Valencia, Spain
CIBER en Epidemiología y Salud Pública, Madrid, Spain
Rufián-Henares JÁ:
Departamento de Nutrición y Bromatología, Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain
Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain
Planes FJ:
Bioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, Spain
Bioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, Spain
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