Fatty acid intake and breast cancer in the Spanish multicase-control study on cancer (MCC-Spain)
Por:
Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Gracia-Lavedan E, Pérez-Gómez B, Oribe M, Martín V, Guevara M, Rodríguez-Cundín P, Fernández-Tardón G, Marcos-Gragera R, Molina-Barcelo, A, Díaz-Santos M, Castaño-Vinyals G, Aragonés N, López-Gonzalez A, Amiano P, Castilla J, Alonso-Molero J, Kogevinas M, Pollán M and Llorca J
Publicada:
1 abr 2020
Ahead of Print:
8 may 2019
Resumen:
Purpose To evaluate the association between dietary fat and fat subtype and breast cancer development. Methods We conducted a case-control study with 1181 cases of incident breast cancer, diagnosed between 2007 and 2012, and 1682 population controls frequency matched (by age, sex, and region) from the Spanish multicenter case-control study MCC-Spain. Results We found a significant protective effect in premenopausal women of total fat intake [OR 0.51 95% CI (0.31-0.86) highest versus lowest tertile], but no effect was observed in menopausal women [OR 1.15 95% CI (0.83-1.60)]. Analyzing by type of fat, this protective effect persisted only for the monounsaturated fatty acids [OR 0.51 95% CI (0.32-0.82)]. In contrast, other fatty acids did not have a significant effect. In addition, a protection against risk of breast cancer was found when polyunsaturated fats were "substituted" by monounsaturated, maintaining the same total fat intake [OR 0.68 95% CI (0.47-0.99)]. Finally, analyzing by breast cancer subtype, we found no effect, except in premenopausal women where intake of moderate [OR 0.52 95% CI (0.33-0.82)] and high monounsaturated fatty acids [OR 0.47 95% CI (0.27-0.82)] maintains a protective effect against ER/PR + tumors. In contrast, in menopausal women, a high intake of monounsaturated fatty acids was associated with higher risk of HER2 + tumors [OR 2.00 95% CI (0.97-4.13)]. Conclusion Our study shows a differential effect of monounsaturated fatty acids according to menopausal status and breast cancer subtype.
Filiaciones:
Dierssen-Sotos T:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain.
Facultad de Medicina, Universidad de Cantabria-IDIVAL, Avda. Herrera Oria s/n, 39011, Santander, Spain.
Gómez-Acebo I:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Facultad de Medicina, Universidad de Cantabria-IDIVAL, Avda. Herrera Oria s/n, 39011, Santander, Spain
Palazuelos C:
Facultad de Medicina, Universidad de Cantabria-IDIVAL, Avda. Herrera Oria s/n, 39011, Santander, Spain
Gracia-Lavedan E:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Pérez-Gómez B:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Cardiovascular and Metabolic Diseases Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Oribe M:
Public Health Division of Gipuzkoa, Health Department, BioDonostia Research Institute, San Sebastian, Basque Country, Spain
Martín V:
Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain
Guevara M:
Instituto de Salud Pública de Navarra, IdiSNA, Pamplona, Spain
Rodríguez-Cundín P:
Servicio de Medicina Preventiva, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Fernández-Tardón G:
IUOPA, Universidad De Oviedo, Asturias, Spain
Marcos-Gragera R:
Research Group on Statistics, Econometrics and Health (GRECS), Universitat de Girona, Girona, Spain
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona, Spain
:
Cancer and Public Health Area, FISABIO-Public Health, Valencia, Spain
Díaz-Santos M:
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain
Castaño-Vinyals G:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Aragonés N:
Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
López-Gonzalez A:
Servicio de Oncología, Complejo Asistencial Universitario de León, Leon, Spain
Amiano P:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Public Health Division of Gipuzkoa, Health Department, BioDonostia Research Institute, San Sebastian, Basque Country, Spain
Castilla J:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Instituto de Salud Pública de Navarra, IdiSNA, Pamplona, Spain
Alonso-Molero J:
Facultad de Medicina, Universidad de Cantabria-IDIVAL, Avda. Herrera Oria s/n, 39011, Santander, Spain
Kogevinas M:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Pollán M:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Cancer Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Llorca J:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología Y Salud Pública-CIBERESP), Madrid, Spain
Facultad de Medicina, Universidad de Cantabria-IDIVAL, Avda. Herrera Oria s/n, 39011, Santander, Spain
ISGlobal, Barcelona, Spain
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