Influence of the Urban Exposome on Birth Weight
Por:
Nieuwenhuijsen, M, Agier, L, Basagaña X, Urquiza, J, Tamayo-Uria, I, Giorgis-Allemand, L, Robinson, O, Siroux, V, Maitre, L, de Castro, M, Valentin, A, Donaire, D, Dadvand, P, Aasvang, G, Krog, N, Schwarze, P, Chatzi, L, Grazuleviciene, R, Andrusaityte, S, Dedele, A, McEachan, R, Wright, J, West, J, Ibarluzea, J, Ballester, F, Vrijheid, M and Slama, R
Publicada:
1 abr 2019
Resumen:
BACKGROUND: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.
OBJECTIVE: We evaluated the association of the urban exposome with birth weight.
METHODS: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures.
RESULTS: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis.
CONCLUSION: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures.
Filiaciones:
Nieuwenhuijsen, M:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Agier, L:
4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France
Basagaña X:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Urquiza, J:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Tamayo-Uria, I:
5 Department of Statistics, Faculty of Arts and Sciences, Harvard University , Cambridge, Massachusetts, USA
Giorgis-Allemand, L:
4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France
Robinson, O:
6 MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , London, UK
Siroux, V:
4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France
Maitre, L:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
de Castro, M:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Valentin, A:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Donaire, D:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Dadvand, P:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Aasvang, G:
7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway
Krog, N:
7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway
Schwarze, P:
7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway
Chatzi, L:
6 MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , London, UK
8 Department of Preventive Medicine, Keck School of Medicine, University of Southern California , Los Angeles, USA
9 Department of Social Medicine, University of Crete , Greece
10 Department of Genetics Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University , Maastricht, Netherlands
Grazuleviciene, R:
11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania
Andrusaityte, S:
11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania
Dedele, A:
11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania
McEachan, R:
12 Bradford Institute for Health Research Bradford , Bradford, UK
Wright, J:
12 Bradford Institute for Health Research Bradford , Bradford, UK
West, J:
12 Bradford Institute for Health Research Bradford , Bradford, UK
Ibarluzea, J:
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
13 Faculty of Psychology, University of the Basque Country UPV/EHU , San Sebastian, Basque Country, Spain
14 Health Research Institute, BIODONOSTIA , San Sebastian, Basque Country, Spain
15 Sub-Directorate for Public Health of Gipuzkoa, Department of Health, Government of the Basque Country , San Sebastian, Basque Country, Spain
:
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
16 Nursing School, Universitat de València , Valencia, Spain
17 Joint Research Unit of Epidemiology and Environmental Health, FISABIO-Universitat Jaume I-Universitat de València , Valencia, Spain
Vrijheid, M:
1 ISGlobal (Institute for Global Health) , Barcelona, Spain
2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain
3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain
Slama, R:
4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France
gold, Green Published, Green Accepted
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