THE EFFECTS OF AGING ON DOPAMINERGIC NEUROTRANSMISSION A microPET STUDY OF [11C]-raclopride BINDING IN THE AGED RODENT BRAIN
Por:
Hoekzema, E, Herance, R, Rojas, S, Pareto, D, Abad, S, Jimenez, X, Figueiras, F, Popota, F, Ruiz, A, Torrent, E, Fernandez Soriano, F, Rocha, M, Rovira, M, Victor, V and Gispert, J
Publicada:
29 dic 2010
Categoría:
Neuroscience (miscellaneous)
Resumen:
Rodent models are frequently used in aging re search to investigate biochemical age effects and aid in the development of therapies for pathological and non pathological age related degenerative processes In order to validate the use of animal models in aging research and pave the way for longitudinal intervention based animal studies, the consistency of cerebral aging processes across species needs to be evaluated The dopaminergic system seems particularly susceptible to the aging process, and one of the most consistent findings in human brain aging research is a decline in striatal D2-like receptor (D2R) availability, quantifiable by positron emission tomography (PET) imaging In this study we aimed to assess whether similar age effects can be discerned in rat brains, using in vivo molecular imaging with the radioactive compound [C-11] raclopride We observed a robust decline in striatal [C-11] raclopride uptake in the aged rats in comparison to the young control group, comprising a 41% decrement in striatal binding potential In accordance with human studies, these results indicate that substantial reductions in D2R availability can be measured in the aged striatal complex Our findings suggest that rat and human brains exhibit similar biochemical alterations with age in the striatal dopaminergic system, providing support for the pertinence of rodent models in aging research (C) 2010 IBRO Published by Elsevier Ltd All rights reserved
Filiaciones:
Hoekzema, E:
Univ Autonoma Barcelona, Dept Psiquiatria & Med Legal, Barcelona 08192, Spain
Herance, R:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Rojas, S:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Pareto, D:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
CIBER BBN, Zaragoza 50018, Spain
Abad, S:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Jimenez, X:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Figueiras, F:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Popota, F:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Ruiz, A:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Torrent, E:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
Fernandez Soriano, F:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
:
Univ Hosp Doctor Peset Fdn, Valencia 46017, Spain
CIBERehd, Valencia 46017, Spain
Rovira, M:
CRC Corp Sanitaria, Barcelona 08006, Spain
:
Univ Hosp Doctor Peset Fdn, Valencia 46017, Spain
CIBERehd, Valencia 46017, Spain
Univ Valencia, Dept Physiol, Valencia 46010, Spain
Gispert, J:
CRC Corp Sanitaria, PRBB, Inst Alta Tecnol, Barcelona 08003, Spain
CIBER BBN, Zaragoza 50018, Spain
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