A single acute dose of pinitol from a naturally-occurring food ingredient decreases hyperglycaemia and circulating insulin levels in healthy subjects
Por:
Hernandez-Mijares, A, Banuls, C, Peris, J, Monzo, N, Jover, A, Bellod, L, Victor, V and Rocha, M
Publicada:
15 nov 2013
Resumen:
A limited amount of research suggests that oral ingestion of pinitol (3-O-methyl-D-chiro-inositol) positively influences glucose tolerance in humans. This study assessed the effects of different doses of pinitol supplementation on glucose tolerance, insulin sensitivity and plasma pinitol concentrations. Thirty healthy subjects underwent two one-day trials in which they consumed a nutritive beverage (Fruit Up (R)) containing 2.5, 4.0 or 6.0 g of pinitol and a corresponding placebo equivalent in both energy and carbohydrates. Blood samples were collected frequently over the 240-min test period. The pinitol-enriched beverage reduced serum glucose and insulin at 45 and 60 min, but only at a dose of 6.0 g. Plasma pinitol concentrations, maximum concentration and AUC increased according to the dose administered. The results show that a single dose of pinitol from a naturally-occurring food ingredient at the highest dose administered acutely influences indices of whole-body glucose tolerance and insulin sensitivity in healthy subjects. (C) 2013 Elsevier Ltd. All rights reserved.
Filiaciones:
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Peris, J:
Univ Valencia, Fac Pharm, Dept Pharm & Pharmaceut Technol, Burjassot 46100, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
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