Involvement of leucocyte/endothelial cell interactions in anorexia nervosa
Por:
Victor, V, Rovira-Llopis, S, Saiz-Alarcon, V, Sangueesa, M, Rojo-Bofill, L, Banuls, C, de Pablo, C, Alvarez, A, Rojo, L, Rocha, M and Hernandez-Mijares, A
Publicada:
1 jul 2015
Resumen:
BackgroundAnorexia nervosa is a common psychiatric disorder in adolescence and is related to cardiovascular complications. Our aim was to study the effect of anorexia nervosa on metabolic parameters, leucocyte-endothelium interactions, adhesion molecules and proinflammatory cytokines.
Materials and MethodsThis multicentre, cross-sectional, case-control study employed a population of 24 anorexic female patients and 36 controls. We evaluated anthropometric and metabolic parameters, interactions between leucocytes polymorphonuclear neutrophils (PMN) and human umbilical vein endothelial cells (HUVEC), proinflammatory cytokines such as tumour necrosis factor alpha (TNF-) and interleukin-6 (IL-6) and soluble cellular adhesion molecules (CAMs) including E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1).
ResultsAnorexia nervosa was related to a decrease in weight, body mass index, waist circumference, systolic blood pressure, glucose, insulin and HOMA-IR, and an increase in HDL cholesterol. These effects disappeared after adjusting for BMI. Anorexia nervosa induced a decrease in PMN rolling velocity and an increase in PMN rolling flux and PMN adhesion. Increases in IL-6 and TNF- and adhesion molecule VCAM-1 were also observed.
ConclusionsThis study supports the hypothesis of an association between anorexia nervosa, inflammation and the induction of leucocyte-endothelium interactions. These findings may explain, in part at least, the increased risk of vascular disease among patients with anorexia nervosa.
Filiaciones:
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Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain
Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain
Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain
Univ Valencia, Dept Physiol, Valencia, Spain
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Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain
Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain
Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain
Saiz-Alarcon, V:
Univ Valencia, Psychiat Serv, Univ Hosp La Fe, Dept Med, Valencia, Spain
Sangueesa, M:
Univ Valencia, Psychiat Serv, Univ Hosp La Fe, Dept Med, Valencia, Spain
Rojo-Bofill, L:
Univ Valencia, Psychiat Serv, Univ Hosp La Fe, Dept Med, Valencia, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain
Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain
Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain
:
Univ Valencia, Dept Pharmacol, Valencia, Spain
Univ Valencia, CIBER Res Grp CB06 04 0071, CIBER Hepat & Digest Dis, Valencia, Spain
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Univ Valencia, Dept Pharmacol, Valencia, Spain
Univ Valencia, CIBER Res Grp CB06 04 0071, CIBER Hepat & Digest Dis, Valencia, Spain
Univ Valencia, Fdn Gen, Valencia, Spain
Rojo, L:
Univ Valencia, Psychiat Serv, Univ Hosp La Fe, Dept Med, Valencia, Spain
Univ Valencia, Res Grp CIBER CIBER Act Epidemiol & Publ Hlth CB, Valencia, Spain
Univ Valencia, Dept Med, Valencia, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain
Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain
Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain
Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain
Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain
Univ Valencia, Dept Med, Valencia, Spain
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