Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes
Por:
Hernandez-Mijares, A, Banuls, C, Rovira-Llopis, S, Alvarez, A, Orden, S, Rubio-Puchol, O, Victor, V and Rocha, M
Publicada:
1 oct 2015
Resumen:
The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte-endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status. (C) 2015 Elsevier Ltd. All rights reserved.
Filiaciones:
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
:
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Pharmacol, Valencia 46010, Spain
:
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Pharmacol, Valencia 46010, Spain
:
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Physiol, Valencia 46010, Spain
:
Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain
Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain
Inst Hlth Res INCLIVA, Valencia 46010, Spain
Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain
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