Invasive fungal infection in crtically ill patients: hurdles and next challenges
Por:
Jose, P, Alvarez-Lerma, F, Maseda, E, Olaechea, P, Peman, J, Soriano, C and Zaragoza, R
Publicada:
17 feb 2019
Ahead of Print:
14 feb 2019
Resumen:
A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device. Possible IFI treatment failures could be related with suboptimal antifungal concentrations despite dose adjustment. Invasive aspergillosis has become an important life-threating infection in intensive care unit related with new risk factors described. IFI remain important problem in critical patients due to the appearance of new risk factors, new species, and resistance increase. Multidisciplinary packages of measures designed to reduce IFI incidence and improve diagnostics tools may reduce the high mortality associated.
Filiaciones:
Jose, P:
a Intensive Care Unit , Hospital General Universitario Gregorio Marañón , Madrid , Spain
Alvarez-Lerma, F:
b Intensive Care Unit , Hospital Universitario del Mar , Barcelona , Spain
Maseda, E:
c Surgical Intensive Care Unit , Hospital Universitario La Paz , Madrid , Spain
Olaechea, P:
d Intensive Care Unit , Hospital Universitario de Galdákano- Usansolo , Galdakao , Spain
Peman, J:
e Microbiology Department , Hospital Universitari i Politecnic La Fe , Valencia , Spain
:
f Intensive Care Unit , Hospital Universitario Ramón y Cajal , Madrid , Spain
:
g Intensive Care Unit , Hospital Universitario Dr. Peset , Valencia , Spain
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