Exposure and risk assessment to arsenic species in Spanish children using biomonitoring
Por:
Yusà V, Pérez R, Sánchez A, Pardo O and Roca M
Publicada:
1 jul 2018
Resumen:
We present a new approach to arsenic (As) risk assessment using biomonitoring. In this pilot study we determined the levels of total and speciated urinary arsenicin 109 Spanish school children aged between 6 and 11 years, and interpreted these concentrations in a risk assessment context. The geometric mean (GM) for total As (TAs) was 33.82 mu/L. The order of occurrence and average concentrations of the different species was arsenobetaine (AsB) (100%, 15 mu g/L), dimethylarsinic (DMA) (97%, 8.32 mu g/L), monomethylarsonic (MMA) (26%, 027 mu g/L) and inorganic As (iAs) (4%, 0.14 mu g/L). 18% of children presented exposures to inorganic arsenic (7.52 mu g/g creatinine) higher than guidance value for non-cancer risk (8.3 mu g/g creatinine). For cancer risk the exposure to inorganic arsenic was much higher than the guidance value. Urinary DMA was positively associated with urinary AsB, suggesting exposure directly to this specie or metabolism of organic arsenicals to this specie, mainly through seafood consumption. Consequently, the exposure to inorganic As needs to be carefully interpreted because it may be overestimated. Our study supports the hypothesis that urinary iAs + MMA is the most reliable biomarker of exposure to inorganic As. (C) 2018 Elsevier B.V. All rights reserved.
Filiaciones:
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[Área de Seguridad Alimentaria_Fisabio SP]. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public, Health, Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain
Laboratory of Public Health of Valencia, 21 Avenida Catalunya, 46020 Valencia, Spain
Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, 50 Doctor Moliner, 46100 Burjassot, Spain
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[Área de Seguridad Alimentaria_Fisabio SP]. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public, Health, Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain
:
[Área de Seguridad Alimentaria_Fisabio SP]. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public, Health, Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain
Laboratory of Public Health of Alicante, 6 Plaza España, 03010 Alicante, Spain
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Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, 50 Doctor Moliner, 46100 Burjassot, Spain
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Analytical Unit, Health Research Institute La Fe, Avenida Abril Martorell, 106, 46026 Valencia, Spain
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