B1a Lymphocytes (CD19+CD5+) Deficiency in Patients with Crohn's Disease and Its Relation with Disease Severity
Por:
Gil-Borras R, García-Ballesteros C, Benet-Campos C, Catalán-Serra I, López-Chuliá F, Cuéllar C and Carlos Andreu-Ballester, J
Publicada:
1 ene 2018
Resumen:
Background/Aims: B1a cells (CD19+CD5+) are considered elements of the innate immune system. The aim of this study was to evaluate the frequency of B1a cells in the peripheral blood of patients with Crohn's disease (CD) and its relation with disease severity. Methods: In this prospective study, a total of 128 subjects (64 CD patients and 64 healthy controls) were studied. B1a cells in peripheral blood, CD Activity Index, and Simple Endoscopic Score of B1a cells were studied. Results: A significant decrease of B1a cells in peripheral blood was observed in patients with CD versus controls (p = 0.002), especially in perforating or penetrating patterns (p = 0.017). A lower frequency of B1a cells is related to increased endoscopic severity (Spearman's Rho: -0.559, p = 0.004). The mean frequency of B1a cells in patients with pre- and post-study surgery was significantly lower than that in patients who did not undergo surgery (p = 0.050 and p = 0.026, respectively). Conclusions: The B1a cell count in peripheral blood is lower in CD patients. This decrease is directly related to the severity of the disease (penetrating or perforating, Simple Endoscopy Score and surgery complication). These results pointed to the fact that B1a cells play an important role in immune protection in CD. (c) 2018 S. Karger AG, Basel.
Filiaciones:
:
Arnau de Vilanova Hosp, Dept Digest, Valencia, Spain
Department of Digestive, Arnau de Vilanova Hospital, Valencia, Spain
:
Arnau de Vilanova Hosp, Dept Hematol, Valencia, Spain
Department of Hematology, Arnau de Vilanova Hospital, Valencia, Spain
:
Arnau de Vilanova Hosp, Dept Hematol, Valencia, Spain
Department of Hematology, Arnau de Vilanova Hospital, Valencia, Spain
Catalán-Serra I:
Helse Nord Trondelag, Levanger Hosp, Dept Gastroenterol, Internal Med, Levanger, Norway
Norwegian Sci & Technol Univ NTNU, Ctr Mol Inflammat Res CEMIR, Trondheim, Norway
Department of Gastroenterology, Internal Medicine, Levanger Hospital, Helse Nord-Trondelag, Levanger, Norway
Centre of Molecular Inflammation Research (CEMIR), Norwegian Science and Technology University (NTNU), Trondheim, Norway
:
Arnau de Vilanova Hosp, Dept Hematol, Valencia, Spain
Department of Hematology, Arnau de Vilanova Hospital, Valencia, Spain
Cuéllar C:
Univ Complutense Madrid, Dept Parasitol, Fac Pharm, Madrid, Spain
Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain
:
Arnau de Vilanova Hosp, Dept Res, San Clemente 12, ES-46015 Valencia, Spain
Department of Research, Arnau de Vilanova Hospital, Valencia, Spain
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