OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients
Por:
Muriel J, Margarit C, Planelles B, Serralta M, Puga C, Inda MD, Cutillas E, Morales D, Horga J and Peiro, A
Publicada:
1 ago 2018
Ahead of Print:
20 may 2018
Resumen:
Screening for opioid use disorder should be considered in chronic non-cancer pain (CNCP) patients with long-term use of opioids. The aim of our study was to assess the effectiveness of an individualized treatment plan (ITP) for prescription opioid dependence that included screening of pharmacogenetic markers. An observational prospective study was performed using prescription opioid-dependent CNCP outpatients (n=88). Patients were divided into nonresponders, responders, or high responders according to their response to the ITP. Genotyping of OPRM1 (A118G), OPRD1 (T921C), COMT (G472A), ABCB1 (C3435T), and ARRB2 (C8622T) was performed by real-time PCR. Our ITP achieved a significant reduction of the morphine equivalent daily dose (MEDD) in 64% of responders, including 33% of high responders. Nonopioid medication or buprenorphine use was significantly higher at final versus basal visit. 118-AA OPRM1 patients required significantly lower MEDD at basal and final visits. Our ITP showed effectiveness and security in reducing MEDD in opioid-dependent patients, with good conversion to buprenorphine that was more pronounced in 118-AA OPRM1 patients.
Filiaciones:
Muriel J:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Miguel Hernandez Univ Elche, Occupat Observ, Elche, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Occupational Observatory, Miguel Hernández University of Elche, Elche, Spain
Margarit C:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Alicante Gen Hosp, Pain Unit, Dept Hlth, Alicante, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Pain Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Planelles B:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Alicante Gen Hosp, Pain Unit, Dept Hlth, Alicante, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Pain Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Serralta M:
Alicante Gen Hosp, Clin Psychol & Psychiat Unit, Dept Hlth, Alicante, Spain
Clinical Psychology and Psychiatry Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Puga C:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Inda MD:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Cutillas E:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Alicante Gen Hosp, Pain Unit, Dept Hlth, Alicante, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Pain Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Morales D:
Miguel Hernandez Univ Elche, Operat Res Ctr, Elche, Spain
Operations Research Centre, Miguel Hernández University of Elche, Elche, Spain
Horga J:
Alicante Gen Hosp, Clin Pharmacol Unit, Dept Hlth, Alicante, Spain
Clinical Pharmacology Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Peiro, A:
ISABIAL FISABIO Fdn, Alicante Gen Hosp, Alicante Inst Hlth & Biomed Res, Neuropharmacol Pain NED Res Grp, C Pintor Baeza 12, Alicante 03010, Spain
Alicante Gen Hosp, Pain Unit, Dept Hlth, Alicante, Spain
Alicante Gen Hosp, Clin Pharmacol Unit, Dept Hlth, Alicante, Spain
Neuropharmacology on Pain (NED) Research Group, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante-General Hospital, Alicante, Spain
Pain Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
Clinical Pharmacology Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
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