Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study
Por:
Valles, X, Henar Alonso, M, Francisco Lopez-Caleya, J, Diez-Obrero, V, Dierssen-Sotos, T, Lope, V, Molina-Barcelo, A, Dolores Chirlaque, M, Juan Jimenez-Moleon, J, Fernandez Tardon, G, Castilla, J, Amiano, P, Capelo, R, Castano-Vinyals, G, Guino, E, Jose Molina de la Torre, A, Moreno-Iribas, C, Perez Gomez, B, Aragones, N, Llorca, J, Martin, V, Kogevinas, M, Pollan, M and Moreno, V
Publicada:
1 dic 2018
Categoría:
Environmental science (miscellaneous)
Resumen:
Objectives: To explore the association of colorectal cancer with environmental solar radiation and sun exposure behavior, considering phenotypic variables (eye color, hair color and skin phenotype), dietary intake of vitamin D and calcium, and socio-demographic factors.
Study design: Multicenter population-based frequency matched case-control study in Spain (MCC-Spain), with 2140 CRC cases and 3950 controls.
Methods: Data were obtained through personal interviews using a structured epidemiological questionnaire that included socio-demographic data, residential history, environmental exposures, behavior, phenotypic and dietary information. An environmental-lifetime sun exposure score was constructed combining residential history and average daily solar radiation, direct and diffuse. Logistic regression was used to explore the association between different variables. A structural equation model was used to verify the associations of the conceptual model.
Results: We found a lower risk of CRC in subjects frequently exposed to sunlight during the previous summer and skin burning due to sun exposure. No association was observed in relation to the residential solar radiation scores. Subjects with light eye or light hair colors had a lower risk of CRC that those with darker colors. Dietary calcium and vitamin D were also protective factors, but not in the multivariate model. The structural equation model analysis suggested that higher sun exposure was associated with a decreased risk of CRC, as well as dietary intake of calcium and vitamin D, and these factors are correlated among themselves and with environmental solar radiation and skin phenotypes.
Conclusion: The results agree with previous observations that sun exposure, dietary vitamin D and calcium intake, and serum 25(OH)D concentration reduce the risk of CRC and indicate that these factors may be relevant for cancer prevention.
Filiaciones:
Valles, X:
Catalan Inst Oncol, Canc Prevent & Control Program, Gran Via 119-203, Lhospitalet De Llobregat 08907, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, Oncobell Program, Lhospitalet De Llobregat, Barcelona, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Henar Alonso, M:
Catalan Inst Oncol, Canc Prevent & Control Program, Gran Via 119-203, Lhospitalet De Llobregat 08907, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, Oncobell Program, Lhospitalet De Llobregat, Barcelona, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Barcelona, Dept Clin Sci, Fac Med & Hlth Sci, Barcelona, Spain
Francisco Lopez-Caleya, J:
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Hosp Cabuenes, Serv Med Interna, Gijon, Asturias, Spain
Diez-Obrero, V:
Catalan Inst Oncol, Canc Prevent & Control Program, Gran Via 119-203, Lhospitalet De Llobregat 08907, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, Oncobell Program, Lhospitalet De Llobregat, Barcelona, Spain
Univ Barcelona, Dept Clin Sci, Fac Med & Hlth Sci, Barcelona, Spain
Dierssen-Sotos, T:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Cantabria, IDIVAL, Santander, Spain
Lope, V:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Carlos III, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Madrid, Spain
:
FISABIO Salud Publ, Area Canc & Salud Publ, Valencia, Spain
Dolores Chirlaque, M:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain
Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain
Juan Jimenez-Moleon, J:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Granada, Dept Prevent Med & Publ Hlth, Fac Med, Granada, Spain
Univ Granada, Hosp Univ Granada, Ibs GRANADA, Granada, Spain
Fernandez Tardon, G:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Oviedo, IUOPA, Inst Oncol, Asturias, Spain
Castilla, J:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona, Navarra, Spain
Amiano, P:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain
Capelo, R:
Univ Huelva, Ctr Invest Recursos Nat Salud & Medio Ambiente RE, Huelva, Spain
Castano-Vinyals, G:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
ISGlobal, Barcelona, Spain
Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain
UPF, Barcelona, Spain
Guino, E:
Catalan Inst Oncol, Canc Prevent & Control Program, Gran Via 119-203, Lhospitalet De Llobregat 08907, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, Oncobell Program, Lhospitalet De Llobregat, Barcelona, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Jose Molina de la Torre, A:
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Moreno-Iribas, C:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona, Navarra, Spain
Perez Gomez, B:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Carlos III, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Madrid, Spain
Aragones, N:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Dept Hlth Madrid, Publ Hlth Div, Epidemiol Sect, Madrid, Spain
Llorca, J:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Cantabria, IDIVAL, Santander, Spain
Martin, V:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Kogevinas, M:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
ISGlobal, Barcelona, Spain
Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain
UPF, Barcelona, Spain
Pollan, M:
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Carlos III, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Madrid, Spain
Moreno, V:
Catalan Inst Oncol, Canc Prevent & Control Program, Gran Via 119-203, Lhospitalet De Llobregat 08907, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, Oncobell Program, Lhospitalet De Llobregat, Barcelona, Spain
Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Barcelona, Dept Clin Sci, Fac Med & Hlth Sci, Barcelona, Spain
Green Published, Green Accepted, hybrid
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