Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
Por:
Domingo-Relloso A, Grau-Perez M, Galan-Chilet I, Garrido-Martinez MJ, Tormos C, Navas-Acien A, Gomez-Ariza JL, Monzo-Beltran L, Saez-Tormo G, Garcia-Barrera T, Dueñas Laita A, Briongos Figuero LS, Martin-Escudero JC, Chaves FJ, Redon J and Tellez-Plaza M
Publicada:
1 feb 2019
Ahead of Print:
5 dic 2018
Categoría:
Environmental science (miscellaneous)
Resumen:
Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population.
Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine(8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study).
Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants.
Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA.
Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
Filiaciones:
Domingo-Relloso A:
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain
Department of Statistics and Operational Research, University of Valencia, Valencia, Spain
Department of Environmental Health Sciences, Columbia University, New York, USA
Grau-Perez M:
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain
Department of Statistics and Operational Research, University of Valencia, Valencia, Spain
Department of Environmental Health Sciences, Columbia University, New York, USA
Galan-Chilet I:
Genomics and Genetic Diagnosis Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain
Garrido-Martinez MJ:
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain
Department of Statistics and Operational Research, University of Valencia, Valencia, Spain
Tormos C:
Department of Biochemistry and Molecular Biology, School of Medicine-INCLIVA, University of Valencia, Valencia, Spain
Navas-Acien A:
Department of Environmental Health Sciences, Columbia University, New York, USA
Gomez-Ariza JL:
Department of Chemistry, University of Huelva, Huelva, Spain
Monzo-Beltran L:
Department of Biochemistry and Molecular Biology, School of Medicine-INCLIVA, University of Valencia, Valencia, Spain
:
Department of Biochemistry and Molecular Biology, School of Medicine-INCLIVA, University of Valencia, Valencia, Spain
Service of Clinical Analyses, University Hospital Doctor Peset, Valencia, Spain
Garcia-Barrera T:
Department of Chemistry, University of Huelva, Huelva, Spain
Dueñas Laita A:
Toxicology Unit, Hospital Universitario Rio Hortega, Valladolid, Spain
Briongos Figuero LS:
Department of Internal Medicine, Hospital Universitario Rio Hortega, Valladolid, Spain
Martin-Escudero JC:
Department of Internal Medicine, Hospital Universitario Rio Hortega, Valladolid, Spain
Chaves FJ:
Genomics and Genetic Diagnosis Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain
CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain
Redon J:
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain
Department of Internal Medicine, Hospital Clínico de Valencia, Valencia, Spain
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institutes, Madrid, Spain
Tellez-Plaza M:
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain
Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain
Department of Environmental Health and Engineering, Johns Hopkins University Baltimore, USA
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