Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women
Por:
Campos-Rodriguez F, Reyes-Nuñez N, Queipo-Corona C, Sanchez-Armengol A, Jurado-Gamez B, Cordero-Guevara J, Troncoso MF, Abad-Fernandez A, Caballero-Rodriguez J, Martin-Romero M, Encabo-Motiño A, Sacristan-Bou L, Navarro-Esteva J, Somoza-Gonzalez M, Masa JF, Sanchez-Quiroga MA, Jara-Chinarro B, Orosa-Bertol B, Martinez-Garcia MA and Spanish Sleep Network
Publicada:
1 abr 2019
Ahead of Print:
13 nov 2018
Categoría:
Pulmonary and respiratory medicine
Resumen:
Objectives: Although an association between uric acid (UA) levels and obstructive sleep apnea (OSA) has been reported, the effect of continuous positive airway pressure (CPAP) on this measure is yet unclear. We aimed to investigate the effect of CPAP therapy on serum UA levels in patients with OSA.
Methods: We conducted a multicenter, open-label, randomized controlled trial in 307 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] >= 15) in 19 Spanish Sleep Units. Women were randomized to CPAP (n =151) or conservative treatment (n =156) for 12 weeks. Changes in serum UA measures were assessed on an intention-to-treat basis. Additional analyses were conducted in the subgroup of women with CPAP adherence >= 4 hinight and those with UA levels >= 6 mg/dl.
Results: Women had a mean (SD) age of 57.1 (10.1) years, median (first-third quartile) body mass index of 33.7 (29.0-38.5) mg/kg(2) and AHI of 32.0 (22.6-48.5). The average serum UA measure was 5.11 (1.26) mg/dl, and 80 (26.1%) participants had UA >= 6 mg/dl. Compared with the control group, the CPAP group did Keywords: not achieve any reduction in UA levels (non-adjusted intergroup difference -0.03 mg/dl, 95%CI-0.20 to 0.13; p = 0.702) after 12 weeks of follow-up. These results did not change when the analysis was restricted to women with CPAP adherence >= 4 h/night, or the subgroup of women with hyperuricemia.
Conclusions: Twelve weeks of CPAP therapy does not reduce UA levels compared to conservative treatment in women with moderate-to-severe OSA. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Campos-Rodriguez F:
Respiratory Department, Hospital Universitario de Valme, Sevilla, Spain
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
Reyes-Nuñez N:
Respiratory Department, Hospital Universitario de Valme, Sevilla, Spain
Queipo-Corona C:
Respiratory Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Sanchez-Armengol A:
Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Sevilla, Spain
Jurado-Gamez B:
Department of Respiratory Medicine, Reina Sofia University Hospital, Institute of Biomedical Research Maimonides (IMIBIC), University of Cordoba, Spain
Cordero-Guevara J:
Unidad de Metodología y Estadística, BioAraba, Vitoria, Spain
Troncoso MF:
Respiratory Department, Fundación Jimenez Diaz, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
Abad-Fernandez A:
Respiratory Department, Hospital Universitario de Getafe, Madrid, Spain
Caballero-Rodriguez J:
Respiratory Department. Hospital Morales Meseguer, Murcia, Spain
Martin-Romero M:
Respiratory Department, Hospital Universitario Virgen de la Victoria, Malaga, Spain
Encabo-Motiño A:
Respiratory Department, Hospital Severo Ochoa, Madrid, Spain
Sacristan-Bou L:
Respiratory Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
Navarro-Esteva J:
Respiratory Department, Hospital Dr. Negrin, Gran Canaria, Spain
Somoza-Gonzalez M:
Respiratory Department, Consorcio Sanitario de Terrassa, Barcelona, Spain
Masa JF:
Respiratory Department, Hospital San Pedro de Alcantara, Caceres, Spain
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
Sanchez-Quiroga MA:
Respiratory Department, Hospital Virgen del Puerto, Caceres, Spain
Jara-Chinarro B:
Respiratory Department, Hospital Puerta de Hierro, Madrid, Spain
:
Respiratory Department, Hospital Dr Peset, Valencia, Spain
Martinez-Garcia MA:
Respiratory Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain
|