Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study
Por:
Gomez-Acebo, I, Dierssen-Sotos, T, de Pedro, M, Perez-Gomez, B, Castano-Vinyals, G, Fernandez-Villa, T, Palazuelos-Calderon, C, Amiano, P, Etxeberria, J, Benavente, Y, Fernandez-Tardon, G, Salcedo-Bellido, I, Capelo, R, Peiro, R, Marcos-Gragera, R, Huerta, J, Tardon, A, Barricarte, A, Altzibar, J, Alonso-Molero, J, Davila-Batista, V, Aragones, N, Pollan, M, Kogevinas, M and Llorca, J
Publicada:
21 sep 2018
Categoría:
Public health, environmental and occupational health
Resumen:
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history.
Methods: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression.
Results: Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (>= 75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4-31.2) in women with acute coronary syndrome, 13.3 (6.2-28.3) in women with strokes and 11.1 (7.8-15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions.
Conclusions: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.
Filiaciones:
Gomez-Acebo, I:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
Dierssen-Sotos, T:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
de Pedro, M:
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
Nuevo Belen Univ Hosp, Dept Obstet & Gynecol, Madrid, Spain
Perez-Gomez, B:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Carlos III Inst Hlth, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Avda Monforte de Lemos 5, Madrid 28029, Spain
IDIPHIM, Inst Hlth Res Puerta de Hierro, Madrid, Spain
Castano-Vinyals, G:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
UPF, Barcelona, Spain
Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain
Fernandez-Villa, T:
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Palazuelos-Calderon, C:
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
Amiano, P:
CIBER Epidemiol & Salud Publ, Madrid, Spain
BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain
Etxeberria, J:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Publ Navarra, Dept Stat & OR, INAMAT, Pamplona, Spain
Benavente, Y:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Catalan Inst Oncol, IDIBELL, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona, Spain
Fernandez-Tardon, G:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Oviedo, Oviedo, Spain
Salcedo-Bellido, I:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Granada, Granada, Spain
Capelo, R:
Univ Huelva, Ctr Invest Recursos Nat Salud & Medio Ambiente RE, Huelva, Spain
:
CIBER Epidemiol & Salud Publ, Madrid, Spain
FISABIO Salud Publ, Fdn Fomento Invest Sanitaria & Biomed Comunidad V, Direcc Gen Salud Publ, Valencia, Spain
Marcos-Gragera, R:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Girona, UERCG, Girona, Spain
Univ Girona, Inst Invest Biomed Girona IdIBGi, Oncol, Girona, Spain
Huerta, J:
CIBER Epidemiol & Salud Publ, Madrid, Spain
IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain
Tardon, A:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Oviedo, Oviedo, Spain
Barricarte, A:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Navarra Publ Hlth Inst, Pamplona, Spain
Navarra Inst Hlth Res IdiSNA, Pamplona, Spain
Altzibar, J:
CIBER Epidemiol & Salud Publ, Madrid, Spain
BioDonostia Res Inst, Osakidetza Basque Hlth Serv, Donostia San Sebastian, Spain
Alonso-Molero, J:
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
Davila-Batista, V:
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Aragones, N:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Carlos III Inst Hlth, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Avda Monforte de Lemos 5, Madrid 28029, Spain
IDIPHIM, Inst Hlth Res Puerta de Hierro, Madrid, Spain
Dept Hlth Madrid, Publ Hlth Div, Epidemiol Sect, Madrid, Spain
Pollan, M:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Carlos III Inst Hlth, Environm & Canc Epidemiol Unit, Natl Ctr Epidemiol, Avda Monforte de Lemos 5, Madrid 28029, Spain
IDIPHIM, Inst Hlth Res Puerta de Hierro, Madrid, Spain
Kogevinas, M:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
UPF, Barcelona, Spain
Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain
Llorca, J:
CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Cantabria, IDIVAL, Fac Med, Avda Herrera Oria S-N, Santander 39011, Spain
Open Access
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