High adherence to the Western, Prudent, and Mediterranean dietary patterns and risk of gastric adenocarcinoma: MCC-Spain study
Por:
Castello A, Fernandez de Larrea N, Martin V, Davila-Batista V, Boldo E, Guevara M, Moreno V, Castano-Vinyals G, Gomez-Acebo I, Fernandez-Tardon G, Peiro R, Olmedo-Requena R, Capelo R, Navarro C, Pacho-Valbuena S, Perez-Gomez B, Kogevinas M, Pollan M, Aragones N and MCC-Spain researchers
Publicada:
1 may 2018
Ahead of Print:
14 nov 2017
Resumen:
Background The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology.
Methods MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age. Risk according to tumor site (cardia, non-cardia) and morphology (intestinal/diffuse) was evaluated using multinomial regression models.
Results A high adherence to the Western pattern increased gastric adenocarcinoma risk [odds ratio(fourth_vs._first_quartile) (95% confidence interval), 2.09 (1.31; 3.33)] even at low levels [odds ratio(second_vs._first_quartile) (95% confidence interval), 1.63 (1.05; 2.52)]. High adherence to the Mediterranean dietary pattern could prevent gastric adenocarcinoma [odds ratio(fourth_vs._first_quartile) (95% confidence interval), 0.53 (0.34; 0.82)]. Although no significant heterogeneity of effects was observed, the harmful effect of the Western pattern was stronger among older participants and for non-cardia adenocarcinomas, whereas the protective effect of the Mediterranean pattern was only observed among younger participants and for non-cardia tumors.
Conclusion Decreasing the consumption of fatty and sugary products and of red and processed meat in favor of an increase in the intake of fruits, vegetables, legumes, olive oil, nuts, and fish might prevent gastric adenocarcinoma.
Filiaciones:
Castello A:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain.
Faculty of Medicine, University of Alcala, Alcala de Henares, Madrid, Spain.
Fernandez de Larrea N:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Martin V:
The Research Group in Gene-Environment and Health Interactions, Vegazana Campus, University of Leon, Leon, Spain
Davila-Batista V:
The Research Group in Gene-Environment and Health Interactions, Vegazana Campus, University of Leon, Leon, Spain
Boldo E:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Guevara M:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Public Health Institute of Navarra, IdiSNA, Pamplona, Spain
Moreno V:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Campus de Bellvitge, L'Hospitalet de Llobregat, Spain
Unit of Biomarkers and Susceptibility, Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), IDIBELL, Gran Via km 2.7, 08907, L'Hospitalet de Llobregat, Spain
Castano-Vinyals G:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Gomez-Acebo I:
Universidad de Cantabria-IDIVAL, Santander, Spain
Fernandez-Tardon G:
IUOPA, University of Oviedo, Oviedo, Spain
:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública, Valencia, Spain
Olmedo-Requena R:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Instituto de Investigacion Biosanitaria ibs.GRANADA, Complejo Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
Capelo R:
Centro de Investigacion en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, Spain
Navarro C:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
Pacho-Valbuena S:
Servicio de Cirugia General, Complejo Asistencial Universitario de Leon, Leon, Spain
Perez-Gomez B:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Kogevinas M:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Pollan M:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Aragones N:
Cancer Epidemiology Unit, National Centre for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
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