Occupational exposures and mammographic density in Spanish women
Por:
Lope V, Garcia-Perez J, Perez-Gomez B, Pedraza-Flechas AM, Alguacil J, Gonzalez-Galarzo MC, Alba MA, van der Haar R, Cortes-Barragan RA, Pedraz-Pingarron C, Moreo P, Santamarina C, Ederra M, Vidal C, Salas-Trejo D, Sanchez-Contador C, Llobet R and Pollan M
Publicada:
1 feb 2018
Ahead of Print:
26 oct 2017
Categoría:
Public health, environmental and occupational health
Resumen:
Objectives The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.
Methods This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.
Results Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (e(beta)=1.51; 95% CI 1.04 to 2.19), ionising radiation (e(beta)=1.23; 95% CI 0.99 to 1.52) and mould spores (e(beta)=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation.
Conclusions Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.
Filiaciones:
Lope V:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Garcia-Perez J:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Perez-Gomez B:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Pedraza-Flechas AM:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Alguacil J:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Centro de Investigacion en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, Spain
Gonzalez-Galarzo MC:
Center for Research in Occupational Health (CiSAL), Universitat Pompeu Fabra, Barcelona, Spain
Alba MA:
Area de Higiene Industrial, PREMAP Seguridad y Salud S.L.U, Barcelona, Spain
van der Haar R:
Departamento I+D+I, MC Mutual, Barcelona, Spain
Cortes-Barragan RA:
Escuela Nacional de Medicina del Trabajo, Carlos III Institute of Health, Madrid, Spain
Pedraz-Pingarron C:
Direccion General de Salud Publica, Junta de Castilla y Leon, Burgos, Spain
Moreo P:
Aragon Breast Cancer Screening Program, Aragon Health Service, Zaragoza, Spain
Santamarina C:
Servicio de Alertas Epidemioloxicas, Programa Galego Diagnostico Precoz Cancro de Mama, Unidade Central A Coruna, Conselleria de Sanidade, A Coruna, Spain
Ederra M:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Public Health Institute, Navarra Breast Cancer Screening Programme, Pamplona, Spain
Vidal C:
Prevention and Control Program, Catalan Institute of Oncology, Barcelona, Spain
:
Valencia Breast Cancer Screening Program, General Directorate Public Health, Valencia, Spain [Fisabio Salud Pública - Cáncer y Salud Pública]
Sanchez-Contador C:
Direccion General de Salud Publica, Illes Balears, Spain
Llobet R:
Institute of Computer Technology, Universitat Politècnica de València, Valencia, Spain
Pollan M:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiologia y Salud Publica - CIBERESP), Madrid, Spain
Green Accepted
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