Chemical stability of ondansetron hydrochloride with other drugs in admixtures via parenteral; a review
Por:
Estan-Cerezo G, Jimenez-Pulido I, Rodriguez Lucena FJ, Matoses Chirivella C, Soriano-Irigaray L and Navarro-Ruiz A
Publicada:
1 sep 2017
Resumen:
Objective: This review was prepared to offer the most complete information about the use of ondansetron in parenteral admixtures with other drugs.
Method: The search was done from September 2016 to April 2017 by using electronic databases Stabilis (R) and Micromedex (R) solutions, Medline/PubMed and Scholar Google searching publications about ondansetron stability in parenteral infusion when is administered by itself or with other medication.
Results: 49 studies are included with a total of 53 drugs. 15 drugs were found compatible administered with ondansetron in a clinical routine concentration range in intravenous administration. Also, four ternary blends were found compatible and another one was incompatible. Otherwise, 38 drugs were found incompatible.
Conclusions: Compatibility of ondansetron offers a broad number of options to be used to avoid nausea and vomiting symptoms in patients with other concomitant medication.
Filiaciones:
:
Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO.
Open Access
|