Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study
Por:
Castello A, Boldo E, Amiano P, Castano-Vinyals G, Aragones N, Gomez-Acebo I, Peiro R, Jimenez-Moleon JJ, Alguacil J, Tardon A, Cecchini L, Lope V, Dierssen-Sotos T, Mengual L, Kogevinas M, Pollan M, Perez-Gomez B and MCC-Spain researchers
Publicada:
1 feb 2018
Ahead of Print:
22 ago 2017
Categoría:
Urology
Resumen:
Purpose: We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension.
Materials and Methods: MCC-Spain (Multicase-Control Study on Common Tumors in Spain) is a population based, multicase-control study that was done in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiological and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1,277 controls 38 to 85 years old. Three previously identified dietary patterns, including Western, prudent and Mediterranean, were reconstructed using MCC-Spain data. The association of each pattern with prostate cancer risk was assessed by logistic regression models with random, province specific intercepts. Risk according to tumor aggressiveness (Gleason score 6 vs greater than 6) and extension (cT1-cT2a vs cT2b-cT4) was evaluated by multinomial regression models.
Results: High adherence to a Mediterranean dietary pattern rich not only in fruits and vegetables but also in fish, legumes and olive oil was specifically associated with a lower risk of Gleason score greater than 6 prostate cancer (quartile 3 vs 1 relative RR 0.66, 95% CI 0.46-0.96 and quartile 4 vs 1 relative RR 0.68, 95% CI 0.46-1.01, p-trend = 0.023) or with higher clinical stage (cT2b-T4 quartile 4 vs 1 relative RR 0.49, 95% CI 0.25-0.96, p-trend = 0.024). This association was not observed with the prudent pattern, which combines vegetables and fruits with low fat dairy products, whole grains and juices. The Western pattern did not show any association with prostate cancer risk.
Conclusions: Nutritional recommendations for prostate cancer prevention should consider whole dietary patterns instead of individual foods. We found important differences between the Mediterranean dietary pattern, which was associated with a lower risk of aggressive prostate cancer, and Western and prudent dietary patterns, which had no relationship with prostate cancer risk.
Filiaciones:
Castello A:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain
Boldo E:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Amiano P:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Public Health Division of Gipuzkoa, BioDonostia Research Health Institute, San Sebastian
Castano-Vinyals G:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Aragones N:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Gomez-Acebo I:
Universidad de Cantabria - IDIVAL. Avenida Cardenal Herrera Oria s/n, 39011 Santander, Spain
:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Fundacion para el Fomento de la Investigacion Sanitaria y Biomedica de la Comunitat Valenciana FISABIO-Salud Publica. Valencia, Spain
Jimenez-Moleon JJ:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Instituto de Investigacion Biosanitaria de Granada ibs.GRANADA. SAS/University of Granada
Department of Preventive Medicine and Public Health. School of Medicine. University of Granada
Alguacil J:
Centro de Investigacion en Salud y Medio Ambiente (CYSMA). Universidad de Huelva. Campus Universitario de El Carmen, 21071, Huelva, Spain
Tardon A:
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Instituto Universitario de Oncología, Universidad de Oviedo. Facultad de Medicina, Oviedo, Spain
Cecchini L:
Urology Department, Hospital del Mar, Barcelona
Lope V:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Dierssen-Sotos T:
Universidad de Cantabria - IDIVAL. Avenida Cardenal Herrera Oria s/n, 39011 Santander, Spain
Mengual L:
Laboratory and Department of Urology, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Centre de Recerca Biomedica CELLEX, Barcelona, Spain
Kogevinas M:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Pollan M:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Perez-Gomez B:
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Carlos III Institute of Health. Av/Monforte de Lemos, 5, 28029, Madrid, Spain
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