Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea
Por:
Campos-Rodriguez F, Gonzalez-Martinez M, Sanchez-Armengol A, Jurado-Gamez B, Cordero-Guevara J, Reyes-Nunez N, Troncoso MF, Abad-Fernandez A, Teran-Santos J, Caballero-Rodriguez J, Martin-Romero M, Encabo-Motino A, Sacristan-Bou L, Navarro-Esteva J, Somoza-Gonzalez M, Masa JF, Sanchez-Quiroga MA, Jara-Chinarro B, Orosa-Bertol B, Martinez-Garcia MA and Spanish Sleep Network
Publicada:
1 ago 2017
Resumen:
Continuous positive airway pressure (CPAP) reduces blood pressure levels in hypertensive patients with obstructive sleep apnoea (OSA). However, the role of CPAP in blood pressure and the metabolic profile in women has not yet been assessed. In this study we investigated the effect of CPAP on blood pressure levels and the glucose and lipid profile in women with moderate-to-severe OSA.
A multicentre, open-label, randomised controlled trial was conducted in 307 women diagnosed with moderate-to-severe OSA (apnoea-hypopnoea index >= 15 events.h(-1)) in 19 Spanish Sleep Units. Women were randomised to CPAP (n=151) or conservative treatment (n=156) for 12 weeks. Changes in office blood pressure measures as well as in the glucose and lipid profile were assessed in both groups.
Compared with the control group, the CPAP group achieved a significantly greater decrease in diastolic blood pressure (-2.04 mmHg, 95% CI -4.02--0.05; p=0.045), and a nonsignificantly greater decrease in systolic blood pressure (-1.54 mmHg, 95% CI -4.58-1.51; p=0.32) and mean blood pressure (-1.90 mmHg, 95% CI -4.0-0.31; p=0.084). CPAP therapy did not change any of the metabolic variables assessed.
In women with moderate-to-severe OSA, 12 weeks of CPAP therapy improved blood pressure, especially diastolic blood pressure, but did not change the metabolic profile, compared with conservative treatment.
Filiaciones:
Campos-Rodriguez F:
Respiratory Dept, Hospital Universitario de Valme, Sevilla, Spain
Gonzalez-Martinez M:
Respiratory Dept, Hospital Universitario Marques de Valdecilla, Santander, Spain
Sanchez-Armengol A:
Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Sevilla, Spain
Jurado-Gamez B:
Dept of Respiratory Medicine, Reina Sofia University Hospital, Institute of Biomedical Research Maimonides (IMIBIC), University of Cordoba, Spain
Cordero-Guevara J:
Gerencia de Atencion Primaria de Burgos, Burgos, Spain
Troncoso MF:
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
Abad-Fernandez A:
Respiratory Dept, Hospital Universitario de Getafe, Madrid, Spain
Teran-Santos J:
Respiratory Dept, Hospital Universitario de Burgos, Burgos, Spain
Caballero-Rodriguez J:
Respiratory Dept, Hospital Morales Meseguer, Murcia, Spain
Martin-Romero M:
Respiratory Dept, Hospital Universitario Virgen de la Victoria, Malaga, Spain
Encabo-Motino A:
Respiratory Dept, Hospital Severo Ochoa, Madrid, Spain
Sacristan-Bou L:
Respiratory Dept, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
Navarro-Esteva J:
Respiratory Dept, Hospital Dr Negrin, Gran Canaria, Spain
Somoza-Gonzalez M:
Respiratory Dept, Consorcio Sanitario de Terrassa, Barcelona, Spain
Masa JF:
Respiratory Dept, Hospital San Pedro de Alcantara, Caceres, Spain
Sanchez-Quiroga MA:
Respiratory Dept, Hospital Virgen del Puerto, Caceres, Spain
Jara-Chinarro B:
Respiratory Dept, Hospital Puerta de Hierro, Madrid, Spain
:
Respiratory Dept, Hospital Dr Peset, Valencia, Spain
Martinez-Garcia MA:
Respiratory Dept, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Open Access
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