Outbreak of multidrug-resistant tuberculosis in two secondary schools
Por:
Miravet Sorribes L, Arnedo Pena A, Bellido Blasco JB, Romeu García MA, Gil Fortuño M, García Sidro P and Cortés Miró P
Publicada:
1 feb 2016
Categoría:
Pulmonary and respiratory medicine
Resumen:
Objectives: To describe an outbreak of multidrug-resistant tuberculosis
(MDR-TB) in two schools
Methods: This was a prospective, observational study of an outbreak of
MDR-TB in 2 schools located in the towns of Onda and Nules, in the
Spanish province of Castellon, from the moment of detection in November
2008 until November 2014, including patient follow-up and contact
tracing.
Results: Five cases of MDR-TB were diagnosed. Overall attack rate was
0.9%, and among the contacts traced, 66 had latent tuberculous
infection, with an infection rate of 14.4%. Molecular characterization
of the 5 M. tuberculosis isolates was performed by restriction fragment
length polymorphism (RFLP) analysis of the IS6110 sequence. In all 5
patients, cultures were negative at 4-month follow-up, showing the
efficacy of the treatment given. No recurrence has been reported to
date.
Conclusions: In the context of globalization and the increased
prevalence of MDR-TB, outbreaks such as the one presented here are only
to be expected. Contact tracing, strict follow-up of confirmed cases,
the availability of fast diagnostic techniques to avoid treatment delay,
and chemoprophylaxis, together with the molecular characterization of
strains, are still essential (C) 2015 SEPAR. Published by Elsevier
Espana, S.L.U. All rights reserved.
Filiaciones:
:
Sección de Neumología, Hospital La Plana, Villarreal, Castellón, España.
:
Sección de Epidemiología, Centro de Salud Pública, Castellón, España
CIBER-ESP grupo 41
:
Sección de Epidemiología, Centro de Salud Pública, Castellón, España
CIBER-ESP grupo 41
:
Sección de Microbiología, Hospital La Plana, Villarreal, Castellón, España
:
Sección de Neumología, Hospital La Plana, Villarreal, Castellón, España
:
Sección de Neumología, Hospital La Plana, Villarreal, Castellón, España
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