Identification of patients at risk of non-adherence to oral antirheumatic drugs in rheumatoid arthritis using the Compliance Questionnaire in Rheumatology: an ARCO sub-study
Por:
Marras C, Monteagudo I, Salvador G, de Toro FJ, Escudero A, Alegre-Sancho JJ, Raya E, Ortiz A, Carmona L, Mestre Y, Cea-Calvo L and Calvo-Alén J
Publicada:
1 jul 2017
Ahead of Print:
17 may 2017
Resumen:
The ARCO study (Study on Adherence of Rheumatoid Arthritis patients to SubCutaneous and Oral Drugs), a multicenter, non-interventional retrospective study, was primarily designed to assess the percentage of patients [aged >= 18 years with an established rheumatoid arthritis (RA) diagnosis] with non-adherence to prescribed subcutaneous biologicals. This paper reports data for the secondary objective from a subset of patients, namely to evaluate non-adherence to prescribed oral antirheumatic drugs in RA patients in Spain using the validated Compliance Questionnaire Rheumatology (CQR). Patients also completed the Morisky-Green Medication Adherence Questionnaire, Beliefs about Medicines Questionnaire, and a questionnaire (developed and validated in Spain) on patient satisfaction with RA treatment and preferences. A total of 271 patients (76.7% females; mean age 55.6 years) were being treated with oral drugs for RA, of which 234 completed the CQR questionnaire. Non-adherence was reported in 49/234 (20.9%) patients. The proportion of non-adherence in younger patients (aged <= 48 years; 37.5%) was double that recorded in patients aged > 48 years (p = 0.006). Patients with a perception of lower efficacy also had a higher risk of non-adherence (p = 0.012). Multivariable analysis showed that younger age and male gender were independently associated with risk of non-adherence. There was only slight agreement between the CQR and MoriskyGreen assessment tools (kappa coefficient = 0.186), possibly reflecting the fact that both questionnaires measure slightly different aspects of medication adherence. In conclusion, one out of five RA patients was identified as at risk for non-adherence with the CQR, and this was more frequent in younger patients and in males.
Filiaciones:
Marras C:
Hospital Universitario Virgen de Arrixaca, Calle Polideportivo, 5, 30120, Murcia, Spain.
Monteagudo I:
Hospital Universitario Gregorio Marañón, Madrid, Spain
Salvador G:
Hospital Universitario Mutua de Terrassa, Barcelona, Spain
de Toro FJ:
Hospital Universitario A Coruña, A Coruña, Spain
Escudero A:
Hospital Universitario Reina Sofía, Córdoba, Spain
:
Hospital Universitario Dr Peset, Valencia, Spain
Raya E:
Hospital Universitario San Cecilio, Granada, Spain
Ortiz A:
Hospital Universitario La Princesa, IIS La Princesa, Madrid, Spain
Carmona L:
Instituto de Salud Musculoesquelética, Madrid, Spain
Mestre Y:
Medical Affairs, Merck Sharp & Dohme, Madrid, Spain
Cea-Calvo L:
Medical Affairs, Merck Sharp & Dohme, Madrid, Spain
Calvo-Alén J:
Hospital Txagorritxu, Araba, Vitoria, Spain
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