Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis
Por:
Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martínez-Costa L and Blanco Alonso R
Publicada:
1 sep 2016
Categoría:
Rheumatology
Resumen:
Introduction: Anterior uveitis is the most common type of intraocular inflammation. Those associated to HLA-B27 represent 18 to 32% of all anterior uveitis cases.
Objectives: To describe clinical characteristics, systemic treatment need, and frequency and type of ocular complications in a cohort of patients diagnosed with HLAB27-related anterior uveitis and in a cohort of patients diagnosed with HLA-B27 non-related anterior uveitis.
To establish if statistically significant differences between both cohorts exist.
Material and methods: We performed a retrospective cohort study including patients with non infectious anterior uveitis related and not related to the antigen HLA-B27.
Result: 162 patients were included, 58 diagnosed with HLA-B27-related anterior uveitis (cohort HLA-B27+1) and 104 diagnosed with HLA-B27-non related anterior uveitis (cohort HLA-B27-).
No statistically significant differences were found regarding clinical characteristics between both cohorts with the exception of a higher frequency of recurrences in cohort HLA-B27+ and a higher frequency of chronic uveitis in cohort HLA-B27-. No differences were found regarding systemic treatment use nor development of ocular complications.
Discussion: In contrast to previous studies, we neither found higher male gender predominance in the cohort of patients with HLA-B27-related anterior uveitis, Nor did we find differences regarding average age, laterality, development of complications nor use of systemic corticosteroids. (C) 2015 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia y Colegio Mexicano de Reumatologia. All rights reserved.
Filiaciones:
:
Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, España.
:
Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, España
:
Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, España
:
Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, España
Blanco Alonso R:
Servicio de Reumatología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España
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