Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China
Por:
Zhang Y, Wu P, Feng L, Yang P, Pan Y, Feng S, Qin Y, Zheng J, Puig-Barberà J, Muscatello D, MacIntyre R, Cowling BJ, Yu H and Wang Q
Publicada:
25 may 2017
Ahead of Print:
26 abr 2017
Resumen:
Background: Vaccination is recommended to prevent influenza virus infection and associated complications. This study aimed to estimate the influenza vaccine effectiveness (VE) against hospitalization in the 2015/16 season in Beijing.
Methods: Patients who were hospitalized in the 5 study hospitals between 1 Oct 2015 and 15 May 2016 were recruited. Influenza vaccination status was obtained for PCR-confirmed influenza patients and the selected controls who tested negative for the virus. Conditional logistic regression was used to estimate the influenza VE matching by calendar week, and adjusting for age, study sites, underlying medical conditions, smoking status, and hospital admissions over the past 12 months.
Results: The overall VE was 37.9% (95% CI: -103.3, 6.5) against laboratory-confirmed influenza associated hospitalization. The 2015-16 seasonal vaccine was had 61.9% (95% CI: -211.9, 15.9), 5.4% (95% CI: -108.1, 46.6) and -45.2% (95% CI: -152.6, 16.5) effectiveness to prevent infection from A(H1N1)pdm09, A(H3N2) and influenza B, respectively.
Conclusions: Influenza vaccination did not show effective protection against hospitalization with influenza in 2015/16 season in Beijing. (C) 2017 Elsevier Ltd. All rights reserved.
Filiaciones:
Zhang Y:
Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China
Wu P:
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region
Feng L:
Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China
Yang P:
Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China
Pan Y:
Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China
Feng S:
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region
Qin Y:
Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China
Zheng J:
Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China
:
Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain
Muscatello D:
School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia
MacIntyre R:
School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia
Cowling BJ:
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Yu H:
School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Wang Q:
Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China.
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